Arabinofuranan_3-O-arabinosyltransferase

Arabinofuranan 3-O-arabinosyltransferase

Arabinofuranan 3-O-arabinosyltransferase

Class of enzymes

Arabinofuranan 3-O-arabinosyltransferase (EC 2.4.2.47, AftC) is an enzyme with systematic name alpha-(1->5)-arabinofuranan:trans,octacis-decaprenylphospho-beta-D-arabinofuranose 3-O-alpha-D-arabinofuranosyltransferase.[1][2] This enzyme catalyses the following chemical reaction:

Adds an alpha-D-arabinofuranosyl group from trans,octacis-decaprenylphospho-beta-D-arabinofuranose at the 3-O-position of an alpha-(1->5)-arabinofuranan chain attached to a beta-(1->5)-galactofuranan chain
Quick Facts Identifiers, EC no. ...

This enzyme is isolated from Mycobacterium smegmatis.

References

  1. [1]
    Birch HL, Alderwick LJ, Bhatt A, Rittmann D, Krumbach K, Singh A, Bai Y, Lowary TL, Eggeling L, Besra GS (September 2008). "Biosynthesis of mycobacterial arabinogalactan: identification of a novel alpha(1-->3) arabinofuranosyltransferase". Molecular Microbiology. 69 (5): 1191–206. doi:10.1111/j.1365-2958.2008.06354.x. PMC 2610374. PMID 18627460.
  2. [2]
    Zhang J, Angala SK, Pramanik PK, Li K, Crick DC, Liav A, Jozwiak A, Swiezewska E, Jackson M, Chatterjee D (August 2011). "Reconstitution of functional mycobacterial arabinosyltransferase AftC proteoliposome and assessment of decaprenylphosphorylarabinose analogues as arabinofuranosyl donors". ACS Chemical Biology. 6 (8): 819–28. doi:10.1021/cb200091m. PMC 3158817. PMID 21595486.
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