Archaeosine_synthase

Archaeosine synthase

Archaeosine synthase

Enzyme

Archaeosine synthase (EC 2.6.1.97, ArcS, TgtA2, MJ1022 (gene), glutamine:preQ0-tRNA amidinotransferase) is an enzyme with systematic name L-glutamine:7-cyano-7-carbaguanine aminotransferase.[1][2] This enzyme catalyses the following chemical reaction

L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O L-glutamate + archaeine15 in tRNA
Quick Facts Identifiers, EC no. ...

In Euryarchaeota the reaction is catalysed by ArcS.

References

  1. [1]
    Phillips G, Chikwana VM, Maxwell A, El-Yacoubi B, Swairjo MA, Iwata-Reuyl D, de Crécy-Lagard V (April 2010). "Discovery and characterization of an amidinotransferase involved in the modification of archaeal tRNA". The Journal of Biological Chemistry. 285 (17): 12706–13. doi:10.1074/jbc.M110.102236. PMC 2857094. PMID 20129918.
  2. [2]
    Phillips G, Swairjo MA, Gaston KW, Bailly M, Limbach PA, Iwata-Reuyl D, de Crécy-Lagard V (February 2012). "Diversity of archaeosine synthesis in crenarchaeota". ACS Chemical Biology. 7 (2): 300–5. doi:10.1021/cb200361w. PMC 3289047. PMID 22032275.
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