Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), popularly known as baboon syndrome because of its resemblance to the distinctive red buttocks displayed by female baboons, is a systemic dermatitis characterized by well-demarcated patches of erythema distributed symmetrically on the buttocks.^[1] The cause of the syndrome may be drug-related: i.e., induced by systemic administration of hydroxyzine,^[2] penicillin,^[3] iodinated radio contrast media,^[4] and others.

The typical rash commonly appears on buttocks. This then resembles the colour of a baboon's buttocks. Other areas like upper inner thigh and armpits, may be affected by the rash. The rashes are red and well-defined. The presentation is typically symmetrical and not associated with systemic symptoms.^[5]

Treatment of symmetrical drug related intertriginous and flexural exanthema involves identifying and stopping the causative agent. Topical steroids can help to reduce the redness.^[6]

Baboon syndrome affects both sexes equally, and can occur at any age, but seems to be more common in childhood than in adulthood.^[7]

• Airbag dermatitis
• List of cutaneous conditions