Beauvericin

Beauvericin

Beauvericin

Chemical compound

Beauvericin is a depsipeptide with antibiotic and insecticidal effects belonging to the enniatin family. It was isolated from the fungus Beauveria bassiana, but is also produced by several other fungi, including several Fusarium species;[1][2] it may therefore occur in grain (such as corn, wheat and barley) contaminated with these fungi.[2][3][4] Beauvericin is active against Gram-positive bacteria and mycobacteria, and is also capable of inducing programmed cell death in mammals.[2]

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Chemically, beauvericin is a cyclic hexadepsipeptide with alternating N-methyl-phenylalanyl and D-hydroxy-iso-valeryl residues. Its ion-complexing capability allows beauvericin to transport alkaline earth metal and alkali metal ions across cell membranes.[citation needed]

Beauvericin has in vitro fungicidal effects on Candida parapsilosis when used in combination with the antifungal drug ketoconazole at dosages of 0.1 μg/ml. Increased survivability rates and low cytotoxicity were also observed in mouse models.[5]

References

  1. [1]
    Hamill RL, Higgens CE, Boaz HE, Gorman M (1969). "The structure of beauvericin, a new depsipeptide antibiotic toxic to Artemia salina". Tetrahedron Letters. 10 (49): 4255–4258. doi:10.1016/S0040-4039(01)88668-8.
  2. [2]
    Logrieco A, Moretti A, Castella G, et al. (1998). "Beauvericin Production by Fusarium Species". Appl Environ Microbiol. 64 (8): 3084–8. Bibcode:1998ApEnM..64.3084L. doi:10.1128/AEM.64.8.3084-3088.1998. PMC 106821. PMID 9687479.
  3. [3]
    Logrieco A, Rizzo A, Ferracane R, Ritieni A (2002). "Occurrence of Beauvericin and Enniatins in Wheat Affected by Fusarium avenaceum Head Blight". Appl Environ Microbiol. 68 (1): 82–5. Bibcode:2002ApEnM..68...82L. doi:10.1128/AEM.68.1.82-85.2002. PMC 126553. PMID 11772612.
  4. [4]
    Jestoi M, Rokka M, Yli-Mattila T, Parikka P, Rizzo A, Peltonen K (2004). "Presence and concentrations of the Fusarium-related mycotoxins beauvericin, enniatins and moniliformin in finnish grain samples". Food Additives and Contaminants. 21 (8): 794–802. doi:10.1080/02652030410001713906. PMID 15370831. S2CID 19565366.
  5. [5]
    Zhang L; Yan K; Zhang Y; Huang R; Bian J; Zheng C; Sun H; Chen Z; Sun N; An R; Min F; Zhao W; Zhuo Y; You J; Song Y; Yu Z; Liu Z; Yang K; Gao H; Dai H; Zhang X; Wang J; Fu C; Pei G; Liu J; Zhang S; Goodfellow M; Jiang Y; Kuai J; Zhou G; Chen X.K (2007). "High-throughput synergy screening identifies microbial metabolites as combination agents for the treatment of fungal infections". Proc Natl Acad Sci U S A. 104 (11): 4606–11. Bibcode:2007PNAS..104.4606Z. doi:10.1073/pnas.0609370104. PMC 1838648. PMID 17360571.
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