Shad's career as a producer began with working for Herman Lubinsky at Savoy Records and Al Green at National Records in the 1940s, producing Charlie Parker in addition to blues and R&B material.[2] He founded the first of several labels, Sittin' In With, in 1948, where he produced Lightnin' Hopkins, Sonny Terry and Brownie McGhee, Smokey Hogg, Peppermint Harris, Curley Weaver, and others.[2] In 1951, he was named director of Artists and repertoire (A&R) at Mercury Records, where he founded the EmArcy label.[2] On the subsidiary label he produced, among others, jazz musicians Sarah Vaughan, Maynard Ferguson, the Clifford Brown/Max Roach quintet, Billy Eckstine and Dinah Washington.[2] He also worked in pop (with Patti Page, Vic Damone, and The Platters) and blues (with Hopkins again and Big Bill Broonzy).
Shad formed the Time label in the mid-to-late 1950s and besides the jazz and cocktail pop albums, he had hits with The Bell Notes, and on his Shad label, The Knockouts and The Beau-Marks. He produced Lou Reed's first vocal recordings, "Your Love" and "Merry Go 'Round" for Time in 1962. He also formed the Brent label (primarily for West Coast signings) and had hits with Skip & Flip, The Chevrons and Bertha Tillman.
In 1964, he founded Mainstream Records, where he both reissued his old material and produced new recordings from Shelly Manne, Dizzy Gillespie, Roy Haynes, Blue Mitchell, Buddy Terry, and Pete Yellin. His credits in rock and roll include the debut albums of both Janis Joplin and Ted Nugent (The Amboy Dukes).[2]