Pittsburgh Penguins (2001–2014)

Orpik was drafted in the first round, 18th overall, of the 2000 NHL Entry Draft by the Pittsburgh Penguins. He began his professional career with the Wilkes-Barre/Scranton Penguins of the American Hockey League (AHL) during the 2001–02 season. He made his NHL debut during the 2002–03 season, playing in six games and recording no points. After earning a permanent roster spot on the team the next year, Orpik played in 79 games, registering one goal, nine assists and 127 penalty minutes.

On March 4, 2006, Orpik boarded Carolina Hurricanes forward Erik Cole, fracturing a vertebra in Cole's neck.^[4] Orpik was suspended three games for the illegal hit.^[5] Cole did not return until Game 6 of the 2006 Stanley Cup Finals.

In the summer of 2008, Orpik signed a new six-year, $22.5 million contract with the Penguins.^[6] In October 2008, he was named an alternate captain (interim while Sergei Gonchar was injured) of the Penguins, along with Evgeni Malkin, behind captain Sidney Crosby.

On June 12, 2009, Orpik and the Penguins became Stanley Cup champions by defeating the Detroit Red Wings in Game 7 of the 2009 Stanley Cup Finals.^[7] He was the first native of California to win the Stanley Cup.^{[citation needed]}

On December 17, 2011, Orpik recorded his 100th career point by earning an assist on Evgeni Malkin's goal on Ryan Miller at Consol Energy Center in Pittsburgh.^[8]

On May 11, 2013, Orpik scored the game-winning goal in overtime of Game 6 to eliminate the New York Islanders and advance Pittsburgh to the second round of the 2013 Stanley Cup playoffs; it was his first career Stanley Cup playoff goal.^[9]

On December 7, 2013, Orpik hit Boston Bruins forward Loui Eriksson, resulting in a concussion to the latter. While Orpik lay on the ice due to a confrontation with a Bruins player, Shawn Thornton delivered a punch that concussed Orpik; Thornton was suspended 15 games for the incident.^[10]

Washington Capitals (2014–2019)

On July 1, 2014, the Washington Capitals signed Orpik to a five-year, $27.5 million contract as an unrestricted free agent.^[11]

In Game 2 of Washington's 2016 playoff series against the Pittsburgh Penguins, Orpik delivered an illegal and late hit to Pittsburgh defenseman Olli Määttä, making contact with Määttä's head. Orpik was suspended three games for the late hit and Määttä returned a few games later to finish, and help win, the series.^[12][13]

On April 23, 2018, during his fourth season with the Capitals, in 2017–18, Orpik was Washington's nomination for the King Clancy Memorial Trophy as a player who best exemplifies leadership qualities and gives back to his community.^[14] In the 2018 playoffs, on May 30, 2018, Orpik scored the game-winning goal in Game 2 of the 2018 Stanley Cup Finals against the Vegas Golden Knights. It was also the first time Orpik had scored a goal since February 20, 2016.^[15] On June 7, 2018, Orpik and the Capitals went on to win the Stanley Cup against the Golden Knights in five games. This was the first Stanley Cup for the Capitals and the second finals victory for Orpik.

On June 22, 2018, less than three weeks after winning the Stanley Cup for the second time, and due to salary cap considerations, Orpik was traded by the Capitals to the Colorado Avalanche (alongside goaltender Philipp Grubauer) in exchange for Colorado's second-round pick in the 2018 NHL Entry Draft.^[16] He was immediately informed by Avalanche general manager Joe Sakic that he would be moved to a preferred destination or bought-out from the remaining year of the five-year contract he had initially signed with Washington. He was placed on unconditional waivers the following day and on June 24, he was released to free agency. On July 24, he signed a one-year, $1 million contract to return to Washington.^[17]

Orpik scored the overtime game-winning goal in Game 2 of Washington's opening round 2019 playoff series against the Carolina Hurricanes, giving the Capitals a 2–0 series lead.^[18] This would be Orpik's last NHL goal. Despite this, the Capitals attempt at a Cup repeat would fall short as the Hurricanes went onto eliminate the Capitals in seven games.

On June 25, 2019, Orpik announced his retirement from professional hockey.^[19] Soon after retiring, the Capitals hired Orpik as a Player Development coach.^[20]