Buzz!: Brain of the World is the eighth title in the Buzz! series of quiz video games. The game has 21 regional variations with the game's title being changed depending upon region, but the basic concept behind the game remains the same.^[1]

The questions in Buzz!: Brain of the UK are specifically about UK general knowledge. Wildlife, TV, Sport.^[2] The versions of the game for other countries follow the same pattern except for being slanted towards general knowledge with a connection to that specific country.

Buzz!: Brain of the World was available for the PlayStation 3, PlayStation 2 and PlayStation Portable, the first time that a single title in the Buzz! series has been available on multiple platforms. The PlayStation 3 version of the game features online play and allows access to user created questions on the My Buzz! site, as well as leaderboards. The PlayStation Portable version, like the previous Buzz! game on the system Buzz!: Master Quiz, has a "pass-around" mode to enable up to 6 players to take part in the same quiz.

The PlayStation 2 version of the game follows the same format as previous Buzz! games for the platform, essentially being the same as the PlayStation 3 version but with lower resolution graphics and no online features.