C-type_natriuretic_peptide

Natriuretic peptide precursor C

Natriuretic peptide precursor C

Protein-coding gene in the species Homo sapiens

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[5][6][7] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Quick Facts NPPC, Available structures ...

Function

Structure of C-type natriuretic peptide (human)

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide (CNP), encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[5] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for the A-type natriuretic receptor (NPRA).[8] It is synthesized and secreted from the endothelium in response to many stimuli, for example shear stress (like NO[clarification needed]) and certain proinflammatory cytokines.[9]


References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000163273 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000026241 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: NPPC natriuretic peptide precursor C".
  6. [6]
    Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Research. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189. S2CID 41367489.
  7. [7]
    Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics. 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765.
  8. [8]
    Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides. 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763. S2CID 9083211.
  9. [9]
    Lumsden NG, Khambata RS, Hobbs AJ (2010). "C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target". Current Pharmaceutical Design. 16 (37): 4080–8. doi:10.2174/138161210794519237. PMC 3605774. PMID 21247399.

Further reading


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