CACNA1I

CACNA1I

CACNA1I

Protein-coding gene in the species Homo sapiens

Calcium channel, voltage-dependent, T type, alpha 1I subunit, also known as CACNA1I or Cav3.3 is a protein which in humans is encoded by the CACNA1I gene.[5][6][7]

Quick Facts Identifiers, Aliases ...

Function

Voltage-dependent calcium channels can be distinguished based on their voltage-dependence, deactivation, and single-channel conductance. Low-voltage-activated calcium channels are referred to as 'T' type because their currents are both transient, owing to fast inactivation, and tiny, owing to small conductance. T-type channels are thought to be involved in pacemaker activity, low-threshold calcium spikes, neuronal oscillations and resonance, and rebound burst firing.[5]

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000100346 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000022416 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: CACNA1H calcium channel, voltage-dependent, T type, alpha 1I subunit".
  6. [6]
    Mittman S, Guo J, Emerick MC, Agnew WS (July 1999). "Structure and alternative splicing of the gene encoding alpha1I, a human brain T calcium channel alpha1 subunit". Neurosci. Lett. 269 (3): 121–4. doi:10.1016/S0304-3940(99)00319-5. PMID 10454147. S2CID 140208155.
  7. [7]
    Catterall WA, Perez-Reyes E, Snutch TP, Striessnig J (December 2005). "International Union of Pharmacology. XLVIII. Nomenclature and structure-function relationships of voltage-gated calcium channels". Pharmacol. Rev. 57 (4): 411–25. doi:10.1124/pr.57.4.5. PMID 16382099. S2CID 10386627.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article CACNA1I, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.