Cyclin-dependent kinase 4 inhibitor B also known as multiple tumor suppressor 2 (MTS-2) or p15^INK4b is a protein that is encoded by the CDKN2B gene in humans.^[5][6]

Quick Facts Available structures, PDB ...

CDKN2B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1D9S
Identifiers
Aliases	CDKN2B, CDK4I, INK4B, MTS2, P15, TP15, p15INK4b, cyclin-dependent kinase inhibitor 2B, cyclin dependent kinase inhibitor 2B
External IDs	OMIM: 600431 MGI: 104737 HomoloGene: 55859 GeneCards: CDKN2B
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p21.3 Start 22,002,903 bp[1] End 22,009,305 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4 C4|4 42.15 cM Start 89,224,536 bp[2] End 89,229,276 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in jejunal mucosa oral cavity rectum duodenum gums vagina palpebral conjunctiva adipose tissue amniotic fluid vulva Top expressed in epithelium of stomach jejunum left colon calvaria ileum mucous cell of stomach right lung lobe conjunctival fornix duodenum left lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding cyclin-dependent protein serine/threonine kinase inhibitor activity protein kinase binding Cellular component cytoplasm cytosol nucleus Biological process cellular response to extracellular stimulus megakaryocyte differentiation positive regulation of transforming growth factor beta receptor signaling pathway regulation of cyclin-dependent protein serine/threonine kinase activity mitotic cell cycle checkpoint signaling spleen development cellular response to nutrient negative regulation of G1/S transition of mitotic cell cycle G2/M transition of mitotic cell cycle negative regulation of epithelial cell proliferation cell cycle negative regulation of phosphorylation positive regulation of transcription by RNA polymerase II negative regulation of cell population proliferation negative regulation of cyclin-dependent protein serine/threonine kinase activity cellular senescence Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1030 12579 Ensembl ENSG00000147883 ENSMUSG00000073802 UniProt P42772 P55271 RefSeq (mRNA) NM_078487 NM_004936 NM_007670 RefSeq (protein) NP_004927 NP_511042 NP_031696 Location (UCSC) Chr 9: 22 – 22.01 Mb Chr 4: 89.22 – 89.23 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated, deleted, or disregulated in a wide variety of cancer.^[7][8][9] This gene encodes a cyclin-dependent kinase inhibitor, also known as p15Ink4b protein, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases by cyclin D, thus the encoded protein functions as a cell growth regulator that inhibits cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcripts of this gene encode proteins that share the N-terminal sequence but completely differ in the C-terminus.^[6]

CDKN2B tumor suppressor gene product p15 has been shown to interact with cyclin-dependent kinase 4.^[10][11]