Cytochrome c oxidase polypeptide 7A2, mitochondrial is an enzyme that in humans is encoded by the COX7A2 gene.^[5][6][7]

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COX7A2
Identifiers
Aliases	COX7A2, COX7AL, COX7AL1, COXVIIAL, COXVIIa-L, VIIAL, cytochrome c oxidase subunit 7A2
External IDs	OMIM: 123996 MGI: 1316715 HomoloGene: 36082 GeneCards: COX7A2
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q14.1 Start 75,237,675 bp[1] End 75,250,323 bp[1]
Gene location (Mouse) Chr. Chromosome 9 (mouse)[2] Band 9 E1|9 43.82 cM Start 79,662,643 bp[2] End 79,667,160 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in endothelial cell pancreatic ductal cell right ventricle Brodmann area 23 sperm prefrontal cortex jejunal mucosa palpebral conjunctiva rectum oral cavity Top expressed in facial motor nucleus medial ganglionic eminence digastric muscle otic placode temporal muscle sternocleidomastoid muscle epithelium of stomach triceps brachii muscle intercostal muscle medial vestibular nucleus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function electron transfer activity cytochrome-c oxidase activity Cellular component mitochondrial inner membrane membrane mitochondrion mitochondrial respirasome Biological process proton transmembrane transport electron transport chain regulation of oxidative phosphorylation mitochondrial respirasome assembly Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1347 12866 Ensembl ENSG00000112695 ENSMUSG00000032330 UniProt P14406 P48771 RefSeq (mRNA) NM_001865 NM_009945 RefSeq (protein) NP_001856 NP_001353221 NP_001353222 NP_034075 Location (UCSC) Chr 6: 75.24 – 75.25 Mb Chr 9: 79.66 – 79.67 Mb PubMed search [3] [4]
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Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen.

This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 2 (liver isoform) of subunit VIIa and the polypeptide 2 is present in both muscle and nonmuscle tissues.

In addition to polypeptide 2, subunit VIIa includes polypeptide 1 (muscle isoform), which is present only in muscle tissues, and a related protein, present in all tissues. This gene may have several pseudogenes.^[7]