Cytochrome c oxidase subunit 7C, mitochondrial is an enzyme that in humans is encoded by the COX7C gene.^[3][4]

Quick Facts Identifiers, Aliases ...

COX7C
Identifiers
Aliases	COX7C, cytochrome c oxidase subunit 7C
External IDs	OMIM: 603774 HomoloGene: 135674 GeneCards: COX7C
Gene location (Human) Chr. Chromosome 5 (human)[1] Band 5q14.3 Start 86,617,928 bp[1] End 86,620,962 bp[1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right ventricle left ventricle kidney prefrontal cortex ganglionic eminence biceps brachii dorsolateral prefrontal cortex caudate nucleus Brodmann area 9 nucleus accumbens n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function cytochrome-c oxidase activity Cellular component integral component of membrane mitochondrial inner membrane membrane mitochondrion mitochondrial respiratory chain complex IV Biological process proton transmembrane transport generation of precursor metabolites and energy mitochondrial electron transport, cytochrome c to oxygen Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1350 n/a Ensembl ENSG00000127184 n/a UniProt P15954 n/a RefSeq (mRNA) NM_001867 n/a RefSeq (protein) NP_001858 n/a Location (UCSC) Chr 5: 86.62 – 86.62 Mb n/a PubMed search [2] n/a
Wikidata
View/Edit Human

Close

Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes subunit VIIc, which shares 87% and 85% amino acid sequence identity with mouse and bovine COX VIIc, respectively, and is found in all tissues. A pseudogene COX7CP1 has been found on chromosome 13.^[4]