CXorf49 is a protein, which in humans is encoded by the gene chromosome X open reading frame 49(CXorf49).

The CXorf49 gene has one alias CXorf49B.^[1] The recname A8MYA2 also refers to the protein coded by CXorf49 or CXorf49B.^[2]

CXorf49 is located on the X chromosome at Xq13.1. It is 3912 base pairs long and the gene sequence has 6 exons.^[3] CXorf49 has one protein coding transcript.^[4]

The protein has 514 amino acids and a molecular mass of 54.4 kDa.^[5] The isoelectric point is 9.3. Compared to other human proteins CXorf49 is glycine- and proline-rich, but the protein has lower levels of asparagine, isoleucine, tyrosine and threonine(Statistical Analysis of Protein Sequences, SAPS ^[6]).

The protein CXorf49 has not yet been shown to interact with other proteins (PSICQUIC^[18]).

CXorf49 is found to be one of the components of a small group of the HL-60 cell proteome that were most prone to form 4-Hydroxy-2-nonenal(HNE) adducts, upon exposure to nontoxic (10 μM) HNE concentrations, along with heat shock 60 kDa protein 1.^[19]

Using BLAST^[20] no orthologs for CXorf49 are found in single celled organisms, fungi or plants whose genomes have been sequenced. For multicellular organisms orthologs are found in mammals. The table below show a selection of the mammal orthologs. They are listed after time of divergence from human.