CYP3A7

CYP3A7

CYP3A7

Protein-coding gene in the species Homo sapiens

CYP3A7 is an enzyme belonging to the cytochrome P450 family. It is 503 amino acids in size and shares 87% of its sequence with CYP3A4. It carries out a similar role in fetuses that CYP3A4 serves in adults.[5] The gene location is 7q22.1.[6]

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The CYP3A group of enzymes are the most abundantly expressed members of the cytochrome P450 family in liver. They are responsible for the metabolism of more than 50% of all clinical pharmaceuticals.[7]

The CYP3A7 enzyme hydroxylates testosterone and dehydroepiandrosterone 3-sulphate, which is involved in the formation of estriol during pregnancy. The CYP3A7 gene is part of a cluster of related genes on chromosome 7q21.1. Naturally-occurring readthrough transcription occurs between this gene and the downstream CYP3A51P pseudogene.[8]

Notable alleles

The CYP3A7*1C allele is associated with poor outcomes in some cancer patients, possibly because of the effect of the enzyme on some chemotherapy agents.[9]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000160870 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000029727 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Komori M, Nishio K, Ohi H, Kitada M, Kamataki T (February 1989). "Molecular cloning and sequence analysis of cDNA containing the entire coding region for human fetal liver cytochrome P-450". J. Biochem. 105 (2): 161–3. doi:10.1093/oxfordjournals.jbchem.a122632. PMID 2722762.
  6. [6]
    "Cytochrome P450, Subfamily IIIA, Polypeptide 7". OMIM. Retrieved March 14, 2013.
  7. [7]
    Paulussen A, Lavrijsen K, Bohets H, Hendrickx J, Verhasselt P, Luyten W, Konings F, Armstrong M (July 2000). "Two linked mutations in transcriptional regulatory elements of the CYP3A5 gene constitute the major genetic determinant of polymorphic activity in humans". Pharmacogenetics. 10 (5): 415–24. doi:10.1097/00008571-200007000-00005. PMID 10898111.
  8. [8]
    Public Domain This article incorporates public domain material from "CYP3A7 cytochrome P450 family 3 subfamily A member 7 [ Homo sapiens (human) ]". Reference Sequence collection. National Center for Biotechnology Information.
  9. [9]
    "CYP3A7*1C Allele Associated With Poor Outcomes in CLL, Breast, and Lung Cancer". Archived from the original on 2016-06-16. Retrieved 2016-03-27.


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