Cefonicid
Cefonicid
Chemical compound
Cefonicide (or cefonicid) is a cephalosporin antibiotic.[1]
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AHFS/Drugs.com | Micromedex Detailed Consumer Information |
MedlinePlus | a601206 |
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Formula | C18H18N6O8S3 |
Molar mass | 542.56 g·mol−1 |
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It has a density of 1.92g/cm3.
Injectable semi-synthetic cephalosporin antibiotic related to cefamandole, q.v.
Cefonicid is synthesized conveniently by nucleophilic displacement of the 3-acetoxy moiety of 1 with the appropriately substituted tetrazole thiole 2. The mandelic acid amide C-7 side chain is reminiscent of cefamandole.
- DE 2611270, Berges, David Alan, "Cephalosporin-Derivate [Cephalosporin derivatives]", published 1976-09-30, assigned to SmithKline Corp.
- D. A. Berges, U.S. patent 4,048,311 (1977 to Smith Kline).
- U.S. patent 4,093,723, U.S. patent 4,159,373 (1978, 1979 both to Smith Kline).
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