Pittsburgh Pirates

The Pittsburgh Pirates selected Kuhl in the ninth round of the 2013 Major League Baseball draft.^[3] After signing with the Pirates, he made his professional debut with the Low–A Jamestown Jammers and spent all of 2013 there, going 3–4 with a 2.11 ERA in 13 starts. Kuhl pitched 2014 with the High–A Bradenton Marauders, compiling a 13–5 record and 3.46 ERA in 28 starts, and 2015 with the Double–A Altoona Curve^[4] where he was 11–5 with a 2.48 ERA and 1.14 WHIP in 26 starts. He began 2016 with the Triple–A Indianapolis Indians.

Kuhl was recalled from Indianapolis on June 26, 2016, made his major league debut, and got his first win that same night as the Pirates defeated the Los Angeles Dodgers, 4–3. Kuhl pitched five innings, allowing three runs, four hits, and four walks with five strikeouts in his debut.^[5] He was optioned to Indianapolis on July 16 and recalled on August 9. After his August 9 recall, he spent the remainder of the season with Pittsburgh. In 14 starts for the Pirates he was 5–4 with a 4.20 ERA, and in 16 starts for Indianapolis he pitched to a 6–3 record and 2.37 ERA.^[6]

Kuhl spent all of the 2017 season in the Pirates starting rotation. Kuhl started 31 games, posting an 8–11 record with an ERA of 4.35. On June 30, 2018, Kuhl was placed on the disabled list with a right forearm strain.^[7] He was ruled out for the season at the beginning of September. In 16 starts, he was 5–5 with an ERA of 4.55 in 85 innings. On September 19, Kuhl underwent Tommy John surgery and missed the entire 2019 season.

In 2020, Kuhl made his return to the mound on July 27, and threw 3+2⁄3 scoreless innings in a Pirates 6–5 loss to the Milwaukee Brewers at PNC Park.^[8] He pitched to a 4.27 ERA in 46+1⁄3 innings pitched in 2020. He was also second in the National League in walks allowed. He was non-tendered on November 30, making him a free agent.^[9]

Colorado Rockies

On March 16, 2022, Kuhl signed a one-year contract with the Colorado Rockies.^[10] He threw his first-career complete game shutout on June 27, 2022 against the Dodgers.^[11] In 2022, Kuhl started 27 games for the Rockies, recording a 6–11 record and 5.72 ERA with 110 strikeouts in 137.0 innings pitched.

Washington Nationals

On February 4, 2023, Kuhl signed a minor league contract with the Washington Nationals organization.^[12] On March 30, Kuhl had his contract selected after making the Opening Day roster.^[13] After starting the year in the rotation for Washington, he was moved to the bullpen after a brief stint on the injured list. In 16 total games for the Nationals, Kuhl struggled to an 8.45 ERA with 31 strikeouts across 38+1⁄3 innings pitched. On June 24, Kuhl was designated for assignment after Paolo Espino was recalled from Triple–A Rochester.^[14] On June 26, Kuhl cleared waivers and was released by the Nationals.^[15]

After his release from the Nationals, Kuhl stepped away from baseball for the remainder of the 2023 season in order to assist his wife in her battle with breast cancer.^[16]

Chicago White Sox

On December 29, 2023, Kuhl signed a minor league contract with the Chicago White Sox.^[17]