Chlorcyclizine

Chlorcyclizine

Chlorcyclizine

Chemical compound

Chlorcyclizine (Di-Paralene, Mantadil, Pruresidine, Trihistan) is a first-generation antihistamine of the diphenylmethylpiperazine group marketed in the United States and certain other countries.[1][2][3] It is used primarily to treat allergy symptoms such as rhinitis, urticaria, and pruritus, and may also be used as an antiemetic.[1][2][3] In addition to its antihistamine effects, chlorcyclizine has some anticholinergic, antiserotonergic, and local anesthetic properties.[4][5] It has been studied as a potential treatment for various flaviviruses like hepatitis C and Zika virus.[6][7][8]

Quick Facts Clinical data, AHFS/Drugs.com ...

See also

References

  1. [1]
    Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
  2. [2]
    Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. ISBN 0-412-46630-9.
  3. [3]
    Hall JA, Morton I (1999). Concise dictionary of pharmacological agents: properties and synonyms. Kluwer Academic. ISBN 0-7514-0499-3.
  4. [4]
    Dorland Staff (2008). Dorland Dictionnaire Medical Bilingue Francais-anglais / Anglais-francais: + E-book a Telecharger (French ed.). Elsevier (Educa Books). ISBN 978-2-84299-899-8.
  5. [5]
    Rogóz Z, Skuza G, Sowińska H (November 1981). "The effect of the antihistaminic drugs on the central action of 5-hydroxytryptophan in mice". Polish Journal of Pharmacology and Pharmacy. 33 (4): 459–465. PMID 6120505.
  6. [6]
    He S, Lin B, Chu V, Hu Z, Hu X, Xiao J, et al. (April 2015). "Repurposing of the antihistamine chlorcyclizine and related compounds for treatment of hepatitis C virus infection". Science Translational Medicine. 7 (282): 282ra49. doi:10.1126/scitranslmed.3010286. PMC 6420960. PMID 25855495.
  7. [7]
    Chamoun-Emanuelli AM, Pécheur EI, Chen Z (September 2014). "Benzhydrylpiperazine compounds inhibit cholesterol-dependent cellular entry of hepatitis C virus". Antiviral Research. 109: 141–148. doi:10.1016/j.antiviral.2014.06.014. PMID 25019406.
  8. [8]
    Santos FR, Nunes DA, Lima WG, Davyt D, Santos LL, Taranto AG, Ferreira JM (February 2020). "Identification of Zika Virus NS2B-NS3 Protease Inhibitors by Structure-Based Virtual Screening and Drug Repurposing Approaches". Journal of Chemical Information and Modeling. 60 (2): 731–737. doi:10.1021/acs.jcim.9b00933. PMID 31850756. S2CID 209409716.
Stub icon

This drug article relating to the respiratory system is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article Chlorcyclizine, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.