DATP(dGTP)—DNA_purinetransferase

dATP(dGTP)—DNA purinetransferase

dATP(dGTP)—DNA purinetransferase

Add article description

dATP(dGTP)—DNA purinetransferase (EC 2.6.99.1) is an enzyme with systematic name dATP(dGTP):depurinated-DNA purine transferase.[1][2] This enzyme catalyses the following chemical reaction

(1) dATP + depurinated DNA deoxyribose triphosphate + DNA
(2) dGTP + depurinated DNA deoxyribose triphosphate + DNA
Quick Facts Identifiers, EC no. ...

The purine residue is transferred on to the apurinic site forming a normal glycosylic bond.

References

  1. [1]
    Deutsch WA, Linn S (January 1979). "DNA binding activity from cultured human fibrolasts that is specific for partially depurinated DNA and that inserts purines into apurinic sites". Proceedings of the National Academy of Sciences of the United States of America. 76 (1): 141–4. Bibcode:1979PNAS...76..141D. doi:10.1073/pnas.76.1.141. PMC 382892. PMID 218192.
  2. [2]
    Livneh Z, Elad D, Sperling J (March 1979). "Enzymatic insertion of purine bases into depurinated DNA in vitro". Proceedings of the National Academy of Sciences of the United States of America. 76 (3): 1089–93. Bibcode:1979PNAS...76.1089L. doi:10.1073/pnas.76.3.1089. PMC 383194. PMID 375225.


Stub icon

This enzyme-related article is a stub. You can help Wikipedia by expanding it.
Share this article:

This article uses material from the Wikipedia article DATP(dGTP)—DNA_purinetransferase, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.