DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose_transaminase

dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase

dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase

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DTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose transaminase (EC 2.6.1.89, TylB, TDP-3-keto-6-deoxy-D-glucose 3-aminotransferase, TDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase, dTDP-3-keto-6-deoxy-D-glucose 3-aminotransferase, dTDP-3-dehydro-6-deoxy-D-glucose 3-aminotransferase) is an enzyme with systematic name dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose:2-oxoglutarate aminotransferase.[1] This enzyme catalyses the following chemical reaction

dTDP-3-amino-3,6-dideoxy-alpha-D-glucopyranose + 2-oxoglutarate dTDP-3-dehydro-6-deoxy-alpha-D-glucopyranose + L-glutamate
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This enzyme is a pyridoxal-phosphate protein.

References

  1. [1]
    Melançon CE, Hong L, White JA, Liu YN, Liu HW (January 2007). "Characterization of TDP-4-keto-6-deoxy-D-glucose-3,4-ketoisomerase from the D-mycaminose biosynthetic pathway of Streptomyces fradiae: in vitro activity and substrate specificity studies". Biochemistry. 46 (2): 577–90. doi:10.1021/bi061907y. PMC 2515277. PMID 17209568.
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