Demexiptiline
Demexiptiline
Chemical compound
Demexiptiline (brand names Deparon, Tinoran) is a tricyclic antidepressant (TCA) used in France for the treatment of depression.[2][3] It acts primarily as a norepinephrine reuptake inhibitor similarly to desipramine.[4]
Quick Facts Clinical data, Trade names ...
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Trade names | Deparon, Tinoran |
Routes of administration | Oral |
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Elimination half-life | 35 hours[1] |
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Formula | C18H18N2O |
Molar mass | 278.355 g·mol−1 |
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The synthesis is similar to that reported for Noxiptiline but also differs in a couple of respects.
The condensation between Dibenzosuberenone [2222-33-5] (1) and hydroxylamine (2) gives the oxime, [1021-91-6] (3). Base catalyzed attachment of the sidechain by reaction with 2-Chloro-N-Methylethanamine [32315-92-7] (4) completed the synthesis of demexiptiline (5).
- Dörwald FZ (4 February 2013). Lead Optimization for Medicinal Chemists: Pharmacokinetic Properties of Functional Groups and Organic Compounds. John Wiley & Sons. pp. 313–. ISBN 978-3-527-64565-7.
- Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. p. 301. ISBN 3-88763-075-0.
- Triggle DJ (1996). Dictionary of Pharmacological Agents. Boca Raton: Chapman & Hall/CRC. p. 583. ISBN 0-412-46630-9.
- US 3989844, Schütz S, Behner O, Hoffmeister F, issued 1976, assigned to Bayer AG. & U.S. patent 3,963,778
- DE 1247302, Schütz S, Behner O, Hoffmeister F, issued 1967, assigned to Bayer AG.