The Detroit Titans were the college football team which represented the University of Detroit (now University of Detroit Mercy) from 1896 to 1964. The team posted an undefeated season in 1928, staking a claim to a national title. The program was terminated in 1964 for financial reasons.

Under head coach Gus Dorais in 1928, the Titans won all nine of their games. Several years later Parke H. Davis, considered to be a "major selector" by the NCAA, named the 1928 team to a share of the national championship.^[2]

From 1922 on, the Titans played their home games at University of Detroit Stadium (also known as U of D Stadium, Titan Stadium, and Dinan Field) near McNichols Road (Six Mile Road) and Fairfield Street on the university's McNichols campus.

The football program had incurred large losses since 1951, and was discontinued after the 1964 season.^[3][4] At the time of the sport's termination, university president Rev. Laurence V. Britt stated that the institution "does not currently have and does not foresee any prospects of its having the substantial funds" required to continue the program.^[5]

Detroit was both independent and affiliated with the Missouri Valley Conference.^[6]

• Unknown (1896–)
• Independent (–1947)
• Missouri Valley Conference (1948–1956)
• Independent (1957–1964)