Diacylglycerol_cholinephosphotransferase

Diacylglycerol cholinephosphotransferase

Diacylglycerol cholinephosphotransferase

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In enzymology, a diacylglycerol cholinephosphotransferase (EC 2.7.8.2) is an enzyme that catalyzes the chemical reaction

CDP-choline + 1,2-diacylglycerol CMP + a phosphatidylcholine
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Thus, the two substrates of this enzyme are CDP-choline and 1,2-diacylglycerol, whereas its two products are CMP and phosphatidylcholine.[1]

Classification

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups.

Nomenclature

The systematic name of this enzyme class is CDP choline:1,2-diacylglycerol cholinephosphotransferase. Other names in common use include:

  • 1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase,
  • 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase,
  • 1-alkyl-2-acetylglycerol cholinephosphotransferase,
  • alkylacylglycerol choline phosphotransferase,
  • alkylacylglycerol cholinephosphotransferase,
  • CDP-choline diglyceride phosphotransferase,
  • cholinephosphotransferase,
  • CPT,
  • cytidine diphosphocholine glyceride transferase,
  • cytidine diphosphorylcholine diglyceride transferase,
  • diacylglycerol choline phosphotransferase,
  • phosphocholine diacylglyceroltransferase,
  • phosphorylcholine-glyceride transferase, and
  • sn-1,2-diacylglycerol cholinephosphotransferase.

Biological role

This enzyme participates in 3 metabolic pathways: aminophosphonate metabolism, glycerophospholipid metabolism, and ether lipid metabolism.

References

  1. [1]
    Coleman R, Bell RM (1977). "Phospholipid synthesis in isolated fat cells. Studies of microsomal diacylglycerol cholinephosphotransferase and diacylglycerol ethanolaminephosphotransferase activities". J. Biol. Chem. 252 (9): 3050–6. PMID 192727.
  • Lee TC, Blank ML, Fitzgerald V, Snyder F (1982). "Formation of alkylacyl- and diacylglycerophosphocholines via diradylglycerol cholinephosphotransferase in rat liver". Biochim. Biophys. Acta. 713 (2): 479–83. doi:10.1016/0005-2760(82)90269-7. PMID 6295501.
  • Parthasarathy S, Cady RK, Kraushaar DS, Sladek NE, Baumann WJ (1978). "Inhibition of diacylglycerol:CDPcholine cholinephosphotransferase activity by dimethylaminoethyl p-chlorophenoxyacetate". Lipids. 13 (2): 161–4. doi:10.1007/BF02533260. PMID 204847.
  • Renooij W, Snyder F (1981). "Biosynthesis of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor and a hypotensive lipid) by cholinephosphotransferase in various rat tissues". Biochim. Biophys. Acta. 663 (2): 545–56. doi:10.1016/0005-2760(81)90182-x. PMID 6260215.


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