Dienestrol
Dienestrol
Chemical compound
Dienestrol (INN , USAN ) (brand names Dienoestrol, Denestrolin, Dienol and many others[lower-alpha 1]), also known as dienoestrol (BAN ), is a synthetic nonsteroidal estrogen medication of the stilbestrol group which is or was used to treat menopausal symptoms in the United States and Europe.[1][2][3][4] It has been studied for use by rectal administration in the treatment of prostate cancer in men as well.[5] The medication was introduced in the U.S. in 1947 by Schering as Synestrol and in France in 1948 as Cycladiene.[4] Dienestrol is a close analogue of diethylstilbestrol.[6] It has approximately 223% and 404% of the affinity of estradiol at the ERα and ERβ, respectively.[7]
Dienestrol diacetate (brand names Faragynol, Gynocyrol, others) also exists and has been used medically.[2]