Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol_alpha-1,2-mannosyltransferase

Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase

Class of enzymes

Dolichyl-P-Man:Man6GlcNAc2-PP-dolichol alpha-1,2-mannosyltransferase (EC 2.4.1.259, ALG9, ALG9 alpha1,2 mannosyltransferase, dolichylphosphomannose-dependent ALG9 mannosyltransferase, ALG9 mannosyltransferase, Dol-P-Man:Man6GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase) is an enzyme with systematic name dolichyl beta-D-mannosyl phosphate:D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase.[1][2][3] This enzyme catalyses the following chemical reaction

dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-[D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate
Quick Facts Identifiers, EC no. ...

References

  1. [1]
    Vleugels W, Keldermans L, Jaeken J, Butters TD, Michalski JC, Matthijs G, Foulquier F (August 2009). "Quality control of glycoproteins bearing truncated glycans in an ALG9-defective (CDG-IL) patient". Glycobiology. 19 (8): 910–7. doi:10.1093/glycob/cwp067. PMID 19451548.
  2. [2]
    Cipollo JF, Trimble RB (February 2000). "The accumulation of Man(6)GlcNAc(2)-PP-dolichol in the Saccharomyces cerevisiae Deltaalg9 mutant reveals a regulatory role for the Alg3p alpha1,3-Man middle-arm addition in downstream oligosaccharide-lipid and glycoprotein glycan processing". The Journal of Biological Chemistry. 275 (6): 4267–77. doi:10.1074/jbc.275.6.4267. PMID 10660594.
  3. [3]
    Frank CG, Aebi M (November 2005). "ALG9 mannosyltransferase is involved in two different steps of lipid-linked oligosaccharide biosynthesis" (PDF). Glycobiology. 15 (11): 1156–63. doi:10.1093/glycob/cwj002. PMID 15987956.
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