A drug corridor is a commonly used drug trafficking route that allows for the flow of illicit drugs into, across, and out of countries. The term is often used as a reference to common drug trafficking routes that often flow through major cities.^[1] There are no definitive drug corridors, but rather a series of connected networks which span across the globe. Drug corridors are reported to have a growing impact on drug use and associated crime along routes drug traffickers are known to travel.^[2] One well known drug corridor in the Americas is the Trans-American Corridor.

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Inhabitants of the lower Midwest and South, including Missouri, Arkansas, Tennessee, Kentucky, and the Carolinas, generally dub their locations to be part of the main trans-American drug corridor, as well as those of the Southwestern U.S. states such as Arizona, New Mexico and Texas.^[3] They claim that the major flow of drugs brought in from the Atlantic coast westward flows through their states and that they are in the main drug corridor.^[4]