EBF1

EBF1

EBF1

Protein-coding gene in the species Homo sapiens

Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.[5][6][7]

Quick Facts Available structures, PDB ...

EBF1 controls the expression of key proteins required for B cell differentiation, signal transduction and function.[8][9] The crucial role of this factor is shown in the regulation of expression of SLAM family co-receptors in B-cells.[10] In addition, EBF1 is also noted for its role in chondrogenic differentiation in limb bud mesenchymal progenitor cells.[11]

Interactions

EBF1 has been shown to interact with ZNF423[12] and CREB binding protein.[13]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000164330 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000057098 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Symbol Report: EBF1". HUGO Gene Nomenclature Committee.
  6. [6]
    Milatovich A, Qiu RG, Grosschedl R, Francke U (Jul 1994). "Gene for a tissue-specific transcriptional activator (EBF or Olf-1), expressed in early B lymphocytes, adipocytes, and olfactory neurons, is located on human chromosome 5, band q34, and proximal mouse chromosome 11". Mamm. Genome. 5 (4): 211–5. doi:10.1007/BF00360547. PMID 8012110. S2CID 19839522.
  7. [7]
    "Entrez Gene: EBF1 early B-cell factor 1".
  8. [8]
    Treiber T, Mandel EM, Pott S, Györy I, Firner S, Liu ET, Grosschedl R (2010). "Early B Cell Factor 1 Regulates B Cell Gene Networks by Activation, Repression, and Transcription- Independent Poising of Chromatin". Immunity. 32 (5): 714–725. doi:10.1016/j.immuni.2010.04.013. PMID 20451411.
  9. [9]
    Hagman J, Ramírez J, Lukin K (2012-01-01). "B Lymphocyte Lineage Specification, Commitment and Epigenetic Control of Transcription by Early B Cell Factor 1". Epigenetic Regulation of Lymphocyte Development. Current Topics in Microbiology and Immunology. Vol. 356. pp. 17–38. doi:10.1007/82_2011_139. ISBN 978-3-642-24102-4. ISSN 0070-217X. PMC 3925327. PMID 21735360.
  10. [10]
    Schwartz AM, Putlyaeva LV, Covich M, Klepikova AV, Akulich KA, Vorontsov IE, Korneev KV, Dmitriev SE, Polanovsky OL (2016-10-01). "Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells". Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 1859 (10): 1259–1268. doi:10.1016/j.bbagrm.2016.07.004. PMID 27424222.
  11. [11]
    Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, Jin EJ, Barrett-Jolley R, Zákány R, Matta C (2023-03-29). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. ISSN 1362-4962. PMC 10164575. PMID 36987858.
  12. [12]
    Tsai RY, Reed RR (Jun 1997). "Cloning and functional characterization of Roaz, a zinc finger protein that interacts with O/E-1 to regulate gene expression: implications for olfactory neuronal development". J. Neurosci. 17 (11): 4159–69. doi:10.1523/JNEUROSCI.17-11-04159.1997. PMC 6573535. PMID 9151733.
  13. [13]
    Zhao F, McCarrick-Walmsley R, Akerblad P, Sigvardsson M, Kadesch T (Jun 2003). "Inhibition of p300/CBP by early B-cell factor" (PDF). Mol. Cell. Biol. 23 (11): 3837–46. doi:10.1128/MCB.23.11.3837-3846.2003. PMC 155219. PMID 12748286.

Further reading


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