Bis(5'-adenosyl)-triphosphatase also known as fragile histidine triad protein (FHIT) is an enzyme that in humans is encoded by the FHIT gene.^[5][6]

Quick Facts Available structures, PDB ...

FHIT
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1FHI, 2FHI, 2FIT, 5FIT, 3FIT, 1FIT, 4FIT, 6FIT
Identifiers
Aliases	FHIT, AP3Aase, FRA3B, fragile histidine triad, tríada histidina fràgil, fragile histidine triad diadenosine triphosphatase
External IDs	OMIM: 601153 MGI: 1277947 HomoloGene: 21661 GeneCards: FHIT
Gene location (Human) Chr. Chromosome 3 (human)[1] Band 3p14.2 Start 59,747,277 bp[1] End 61,251,459 bp[1]
Gene location (Mouse) Chr. Chromosome 14 (mouse)[2] Band 14 A1|14 5.61 cM Start 11,307,738 bp[2] End 12,919,681 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right adrenal gland gallbladder oocyte kidney left ventricle gastric mucosa body of pancreas cingulate gyrus left lobe of thyroid gland caudate nucleus Top expressed in motor neuron saccule proximal tubule seminal vesicula pineal gland kidney left colon left lobe of liver ileum lens More reference expression data BioGPS More reference expression data
Gene ontology Molecular function bis(5'-adenosyl)-triphosphatase activity nucleotide binding catalytic activity hydrolase activity protein binding ubiquitin protein ligase binding identical protein binding Cellular component cytoplasm cytosol mitochondrion nucleus fibrillar center plasma membrane Biological process negative regulation of proteasomal ubiquitin-dependent protein catabolic process purine nucleotide metabolic process regulation of transcription, DNA-templated nucleotide metabolic process transcription, DNA-templated intrinsic apoptotic signaling pathway by p53 class mediator apoptotic process Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2272 14198 Ensembl ENSG00000189283 ENSMUSG00000060579 UniProt P49789 O89106 RefSeq (mRNA) NM_001166243 NM_002012 NM_001320899 NM_001320900 NM_001320901 NM_001354589 NM_001354590 NM_010210 NM_001308285 NM_001308286 NM_001360141 RefSeq (protein) NP_001159715 NP_001307828 NP_001307829 NP_001307830 NP_002003 NP_001341518 NP_001341519 NP_001295214 NP_001295215 NP_034340 NP_001347070 Location (UCSC) Chr 3: 59.75 – 61.25 Mb Chr 14: 11.31 – 12.92 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Close

FHIT is also known as human accelerated region 10. It may, therefore, have played a key role in differentiating humans from apes.^[7]

This gene, a member of the histidine triad gene family, encodes a diadenosine P1,P3-bis(5'-adenosyl)-triphosphate adenylohydrolase involved in purine metabolism. The gene encompasses the common fragile site FRA3B on chromosome 3, where carcinogen-induced damage can lead to translocations and aberrant transcripts of this gene. In fact, aberrant transcripts from this gene have been found in about half of all esophageal, stomach, and colon carcinomas.^[8]

Though the exact molecular function of FHIT is still partially unclear, the gene works as a tumor suppressor as it has been demonstrated in animal studies.^[9][10][11] Furthermore FHIT has been shown to synergize with VHL, another tumor suppressor, in protecting against chemically - induced lung cancer.^[12]

FHIT also acts as a tumor suppressor of HER2/neu driven breast cancer.^[13]

FHIT has been shown to interact with UBE2I.^[14]