Fluminorex

Fluminorex

Fluminorex

Chemical compound

Fluminorex is a centrally acting sympathomimetic which is related to other drugs such as aminorex and pemoline. It was developed as an appetite suppressant by McNeil Laboratories in the 1950s.[1][2]

Quick Facts Clinical data, ATC code ...

Synthesis

Synthesis:[3] Patent (Ex XV):[4]

2-amino-1-[4-(trifluoromethyl)phenyl]ethanol [776-02-3] (1) cyanogen bromide [506-68-3] (2)

See also

References

  1. [1]
    US Patent 3278382 - 2-amino-5-aryloxazoline compositions and methods of using same
  2. [2]
    Maier J, Mayer FP, Brandt SD, Sitte HH (October 2018). "DARK Classics in Chemical Neuroscience: Aminorex Analogues". ACS Chemical Neuroscience. 9 (10): 2484–2502. doi:10.1021/acschemneuro.8b00415. PMC 6287711. PMID 30269490.
  3. [3]
    Poos, G. I., Carson, J. R., Rosenau, J. D., Roszkowski, A. P., Kelley, N. M., McGowin, J. (May 1963). "2-amino-5-Aryl-2-oxazolines. Potent New Anorectic Agents". Journal of Medicinal Chemistry. 6 (3): 266–272. doi:10.1021/jm00339a011. PMID 14185981.
  4. [4]
    Poos George Ireland, U.S. patent 3,278,382 (1966 to Janssen Pharmaceuticals Inc).


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