Francesco Barberini, iuniore (12 November 1662 – 17 August 1738) was an Italian Cardinal of the family of Pope Urban VIII (1623–1644) and of the Princes of Palestrina.

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His Eminence Francesco Barberini
Dean of the College of Cardinals
Church	Catholic Church
In office	1726–1738
Other post(s)	Cardinal-Bishop of Ostia e Velletri (1726–1738)
Orders
Ordination	26 September 1700 (deacon) 15 September 1715 (priest)
Consecration	16 Mar 1721 (bishop) by Fabrizio Paolucci
Created cardinal	13 November 1690 by Pope Alexander VIII
Personal details
Born	12 November 1662 Rome, Papal States
Died	17 August 1738 (age 75) Rome, Papal States

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He was born in Rome, the eldest son of Maffeo Barberini and Olimpia Giustiniani (a niece of Pope Innocent X), the nephew of cardinal Carlo Barberini and the grandson of Taddeo Barberini (a nephew of Pope Urban VIII). He was the grand-nephew of Cardinal Francesco Barberini who was also a nephew of Pope Urban.^[1] Francesco was also a cousin of Rinaldo d'Este, Duke of Modena whose mother was his aunt, Lucrezia Barberini.

He gave up his birthright (as eldest son) for an ecclesiastic career thereby making his brother, Urbano Barberini, heir to the Barberini estate. When his sister-in-law, Felice Ventimiglia Pignatelli d'Aragona separated from Urbano, she sought refuge with Francesco and joined a convent within his bishopric. She later bequeathed her dowry to the Cardinal.

He was created cardinal by Pope Alexander VIII on 13 November 1690 with the dispensation of having an uncle (Carlo Barberini) in the Sacred College and for not having yet received the minor orders.^[2] He was named cardinal-deacon of Sant'Angelo in Pescheria although not ordained to the diaconate until ten years later.

He was ordained priest in 1715. He participated in the five papal conclaves (1691, 1700, 1721, 1724 and 1730). Abbot of Farfa and Subiaco from 1704. On 3 Mar 1721, he was named Cardinal-Bishop of Palestrina and on 16 Mar 1721, he was consecrated bishop by Fabrizio Paolucci, Cardinal-Bishop of Albano, with Vincenzo Petra, Titular Archbishop of Damascus, and Bernardo Maria Conti, Bishop Emeritus of Terracina, Priverno e Sezze, serving as co-consecrators.^[2][3]

On 1 July 1726 he was appointed Cardinal-Bishop of Ostia e Velletri. That same year he arranged the kidnapping of his twelve-year-old niece, Cornelia Constance Barberini, in a custody dispute with her mother, Maria Teresa Boncompagni, in order to arrange a marriage between Cornelia and Giulio Cesare Colonna di Sciarra.^[4]

He became dean of the Sacred College of Cardinals in December 1734. He died at his Roman palace, at the age of 75.

In 1704 he commissioned Bernardino Cametti to create funerary monuments for his grandfather Taddeo and great-uncle Antonio Barberini in the family Church of Santa Rosalia in Palestrina.

After the death of Urbano in 1722, Francesco inherited a number of pieces of artwork, including Caravaggio's The Cardsharps.^[5] He also owned Claude Lorrain's Seaport with the Embarkation of Saint Ursula previously owned by his great-uncle Cardinal Francesco Barberini,^[6] and Pietro da Cortona's The Madonna and child with Saint Martina (1645).