GSDMB

GSDMB

GSDMB

Protein-coding gene in the species Homo sapiens

Gasdermin B is a protein that in humans is encoded by the GSDMB gene. [3]

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Function

This gene encodes a member of the gasdermin-domain containing protein family. Other gasdermin-family genes are implicated in the regulation of apoptosis in epithelial cells, and are linked to cancer. Multiple transcript variants encoding different isoforms have been found for this gene. Additional variants have been described, but they are candidates for nonsense-mediated mRNA decay (NMD) and are unlikely to be protein-coding.

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000073605 – Ensembl, May 2017
  2. [2]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. [3]
    "Entrez Gene: Gasdermin B". Retrieved 2016-08-26.

Further reading

  • Katoh M, Katoh M (2004). "Evolutionary recombination hotspot around GSDML-GSDM locus is closely linked to the oncogenomic recombination hotspot around the PPP1R1B-ERBB2-GRB7 amplicon". Int. J. Oncol. 24 (4): 757–63. doi:10.3892/ijo.24.4.757. PMID 15010812.


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