Gadofosveset

Gadofosveset

Gadofosveset

Chemical compound

Gadofosveset (trade names Vasovist, Ablavar) is a gadolinium-based MRI contrast agent. It was used as the trisodium salt monohydrate form.[2][3] It acts as a blood pool agent by binding to human serum albumin. The manufacturer (Lantheus Medical) discontinued production in 2017 due to poor sales.[4]

Quick Facts Clinical data, Trade names ...

Gadofosveset facilitates high-resolution magnetic resonance angiography.[5] Ferumoxytol (trade names Feraheme, Rienso), an intravenous iron-replacement therapy, has been shown to potentially be superior to gadofosveset as a blood pool agent for MR venography in pediatric patients.[6]

References

  1. [1]
    "FDA-sourced list of all drugs with black box warnings (Use Download Full Results and View Query links.)". nctr-crs.fda.gov. FDA. Retrieved 22 Oct 2023.
  2. [2]
    DailyMed: Vasovist
  3. [3]
    Drugs.com: Ablavar
  4. [4]
    Bell D, Morgan M. "Gadofosveset trisodium". Radiopaedia. radiopaedia.org. Retrieved 2018-08-28.
  5. [5]
    Sabach AS, Bruno M, Kim D, Mulholland T, Lee L, Kaura S, Lim RP (June 2013). "Gadofosveset trisodium: abdominal and peripheral vascular applications". AJR. American Journal of Roentgenology. 200 (6): 1378–86. doi:10.2214/AJR.12.8991. PMID 23701079.
  6. [6]
    Shahrouki P, Khan SN, Yoshida T, Iskander PJ, Ghahremani S, Finn JP (March 2022). "High-resolution three‑dimensional contrast‑enhanced magnetic resonance venography in children: comparison of gadofosveset trisodium with ferumoxytol". Pediatric Radiology. 52 (3): 501–512. doi:10.1007/s00247-021-05225-2. PMC 8857136. PMID 34936018.
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