Glycerol-3-phosphate_dehydrogenase_(quinone)

Glycerol-3-phosphate dehydrogenase (quinone)

Glycerol-3-phosphate dehydrogenase (quinone)

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Glycerol-3-phosphate dehydrogenase (EC 1.1.5.3 is an enzyme with systematic name sn-glycerol 3-phosphate:quinone oxidoreductase.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction

sn-glycerol 3-phosphate + quinone glycerone phosphate + quinol
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This flavin-dependent dehydrogenase is a membrane enzyme. It participates in glycolysis, respiration and phospholipid biosynthesis.

References

  1. [1]
    Ringler RL (April 1961). "Studies on the mitochondrial alpha-glycerophosphate dehydrogenase. II. Extraction and partial purification of the dehydrogenase from pig brain". The Journal of Biological Chemistry. 236 (4): 1192–8. doi:10.1016/S0021-9258(18)64266-8. PMID 13741763.
  2. [2]
    Schryvers A, Lohmeier E, Weiner JH (February 1978). "Chemical and functional properties of the native and reconstituted forms of the membrane-bound, aerobic glycerol-3-phosphate dehydrogenase of Escherichia coli". The Journal of Biological Chemistry. 253 (3): 783–8. doi:10.1016/S0021-9258(17)38171-1. PMID 340460.
  3. [3]
    MacDonald MJ, Brown LJ (February 1996). "Calcium activation of mitochondrial glycerol phosphate dehydrogenase restudied". Archives of Biochemistry and Biophysics. 326 (1): 79–84. doi:10.1006/abbi.1996.0049. PMID 8579375.
  4. [4]
    Rauchová H, Fato R, Drahota Z, Lenaz G (August 1997). "Steady-state kinetics of reduction of coenzyme Q analogs by glycerol-3-phosphate dehydrogenase in brown adipose tissue mitochondria". Archives of Biochemistry and Biophysics. 344 (1): 235–41. doi:10.1006/abbi.1997.0150. PMID 9244403.
  5. [5]
    Shen W, Wei Y, Dauk M, Zheng Z, Zou J (February 2003). "Identification of a mitochondrial glycerol-3-phosphate dehydrogenase from Arabidopsis thaliana: evidence for a mitochondrial glycerol-3-phosphate shuttle in plants". FEBS Letters. 536 (1–3): 92–6. Bibcode:2003FEBSL.536...92S. doi:10.1016/s0014-5793(03)00033-4. PMID 12586344.
  6. [6]
    Walz AC, Demel RA, de Kruijff B, Mutzel R (July 2002). "Aerobic sn-glycerol-3-phosphate dehydrogenase from Escherichia coli binds to the cytoplasmic membrane through an amphipathic alpha-helix". The Biochemical Journal. 365 (Pt 2): 471–9. doi:10.1042/BJ20011853. PMC 1222694. PMID 11955283.
  7. [7]
    Ansell R, Granath K, Hohmann S, Thevelein JM, Adler L (May 1997). "The two isoenzymes for yeast NAD+-dependent glycerol 3-phosphate dehydrogenase encoded by GPD1 and GPD2 have distinct roles in osmoadaptation and redox regulation". The EMBO Journal. 16 (9): 2179–87. doi:10.1093/emboj/16.9.2179. PMC 1169820. PMID 9171333.
  8. [8]
    Larsson C, Påhlman IL, Ansell R, Rigoulet M, Adler L, Gustafsson L (March 1998). "The importance of the glycerol 3-phosphate shuttle during aerobic growth of Saccharomyces cerevisiae". Yeast. 14 (4): 347–57. doi:10.1002/(SICI)1097-0061(19980315)14:4<347::AID-YEA226>3.0.CO;2-9. PMID 9559543.
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