Grattan Street is a major street in Melbourne, Australia.

It runs from Flemington Road on the Western side to Rathdowne Street on the Eastern Side.^[1] It is bisected by Elizabeth Street/Royal Parade, Berkeley Street (South), Barry Street (South), Leicester Street (South), Malvina Place (South), Bouverie Street (South), Swanston Street, Cardigan Street, Lygon Street, Watt Lane (South), Drummond Street and Erskine Lane.^[1]

Since 2020, Grattan Street has been split by the building works for a new pedestrian zone adjoining the university, and for the new Parkville train station.^[2]

The street runs through the campus of the University of Melbourne.^[1] Other landmarks include the Melbourne Teachers' College, Borsari's Corner, Graduate House, Melbourne University Regiment and the Royal Melbourne Hospital.