Guylène Pantel (14 December 1963) is a French politician of Socialist Party (PS) who has been serving as a member of the French Senate since 2017, representing Lozère.

Pantel was elected municipal councilor of Ispagnac in the first round of the municipal elections of 2008.^[1] She became the first deputy mayor of this municipality on 4 April 2014, then interim mayor on 28 May 2018. She was elected mayor on 31 July.^[2] She was elected departmental councilor of Lozère for the canton of Florac in 2015, then became fourth vice-president of the departmental council of Lozère on 2 April 2015.^[3][4] In January 2017, she became first vice-president of the newly created community of municipalities Gorges Causses Cévennes.

On 4 March 2020, Pantel became a senator for Lozère following the death of Alain Bertrand.^[5] Following her appointment, not being able to hold these positions, she resigned from her duties as mayor, vice-president of the community of communes^[6] and vice-president of the departmental council.^[7] She was not renewed in her mandate as municipal councilor of Ispagnac during the municipal elections of 2020.^[8]

Pantel was the first member of the Senate and inhabitant of Lozère to have tested positive for COVID-19, on 13 March 2020.^[9]