Homeobox protein Hox-C11 is a protein that in humans is encoded by the HOXC11 gene.^[5][6][7]

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HOXC11
Identifiers
Aliases	HOXC11, HOX3H, homeobox C11
External IDs	OMIM: 605559 MGI: 96193 HomoloGene: 130362 GeneCards: HOXC11
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q13.13 Start 53,973,126 bp[1] End 53,977,643 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 F3|15 58.02 cM Start 102,862,862 bp[2] End 102,866,143 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in popliteal artery skin of abdomen saphenous vein muscle of leg gastrocnemius muscle subcutaneous adipose tissue skeletal muscle tissue Achilles tendon placenta kidney Top expressed in male urethra muscle tissue skeletal muscle tissue quadriceps femoris muscle spinal ganglia neural tube urinary bladder skin of limb kidney yolk sac More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus nucleoplasm cytosol Biological process multicellular organism development embryonic skeletal joint morphogenesis skeletal system development proximal/distal pattern formation embryonic digit morphogenesis endoderm development metanephros development regulation of transcription, DNA-templated organ induction anterior/posterior pattern specification positive regulation of transcription by RNA polymerase II transcription, DNA-templated transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3227 109663 Ensembl ENSG00000123388 ENSMUSG00000001656 UniProt O43248 P31313 RefSeq (mRNA) NM_014212 NM_001024842 RefSeq (protein) NP_055027 NP_001020013 Location (UCSC) Chr 12: 53.97 – 53.98 Mb Chr 15: 102.86 – 102.87 Mb PubMed search [3] [4]
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This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms.

Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, which are located on different chromosomes and consist of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXC genes located in a cluster on chromosome 12. The product of this gene binds to a promoter element of the lactase-phlorizin hydrolase. It also may play a role in early intestinal development. An alternatively spliced variant encoding a shorter isoform has been described but its full-length nature has not been determined.^[7]