Prior to joining CNBC, Gamble worked for ABC News and Fox News in Washington, D.C./
At CNBC, Gamble was an anchor and Senior International Correspondent based in Abu Dhabi, where she presented Capital Connection as well as fronting CNBC's feature franchise Access: Middle East whose guests included King Abdullah II of Jordan, US Secretary of State Mike Pompeo, Blackrock CEO Larry Fink, Egyptian President Abdel Fattah el-Sisi, Facebook's Sean Parker, HRH Princess Reema bin Bandar Al-Saud, Bill Gates, U.S. Treasury Secretary Steven Mnuchin, and U.S. Secretary of Defense Mark Esper.[3]
In October 2018, she interviewed Saudi Foreign Minister Adel Al-Jubeir, the first comment from a Saudi official following Jamal Khashoggi's assassination.[citation needed] She was also the first international journalist to be live on the ground at Aramco oil facilities in September 2019 reporting the damage left by Iranian rockets and drones.[citation needed]
Gamble is the last Western journalist to interview Russian President Vladimir Putin before his invasion of Ukraine;[4] she was criticized by the state-run Russian media for her appearance and body language throughout the interview, even labeling her as a "sex object" and comparing her to Sharon Stone's interrogation scene in Basic Instinct.
Gamble has reported several times from the World Economic Forum in Davos.[3]
Gamble's name was released as being the basis for the sexual harassment complaint against NBCUniversal CEO Jeff Shell that led to his ouster on April 23, 2023.[5] On May 10, 2023 a CNBC spokesperson confirmed "Capital Connection" anchor Gamble's pending departure from the network, with no reason given.[6] She currently runs her own company, Whistlejacket Media.