Harry L. Sain (August 26, 1893 – October 20, 1975) was an American politician who served as alderman of Chicago's 27th ward from 1933 to 1971. He was a longtime associate of ward committeeman John J. Touhy^[1] and a dominant figure in local Democratic politics, turning his ward into one of 11 that could be guaranteed to deliver large Democratic majorities.^[2] He long headed the Committee on Committees and Rules, which was responsible for assigning aldermen to various committees.^[1] Democratic committeeman Ed Quigley decided to replace him with African-American Eugene Ray upon taking office in 1968, by which time the 27th ward had become almost entirely African-American.^[2] In addition to his service on the City Council he served as an alternate delegate to the 1956 Democratic National Convention.^[3] He died of a heart attack in 1975.^[1]

• List of Chicago aldermen since 1923