Herpes_simplex_virus_protein_vmw65
Vmw65, also known as VP16 or α-TIF (Trans Inducing Factor)[2] is a trans-acting protein that forms a complex with the host transcription factors Oct-1 and HCF to induce immediate early gene transcription in the herpes simplex viruses.[3][4]
VP16 is a strong transactivator[5] and is often used in Y2H systems as the activation domain of the system.[6]