Hessa bint Salman Al Khalifa (c. 1933 – 5 August 2009) was a member of the Bahraini royal family, the mother of the current monarch of Bahrain Hamad bin Isa Al Khalifa.

Hessa bint Salman was the consort and widow of the former Emir of Bahrain, Isa bin Salman Al Khalifa, who reigned from 1961 until his death in 1999. They married on 8 May 1949. She was the mother of the current King of Bahrain, Hamad bin Isa Al Khalifa,^[1] the couple's eldest son.

Hessa bint Salman was active in charitable causes during her life.^[2] The Gulf Daily News, a Bahraini newspaper, referred to her as a "pioneer" in the promotion of humanitarian causes within Bahrain and abroad.^[2] Some of Hessa bint Salman Al Khalifa's most noteworthy projects included the care of orphans, aid to women who were divorced or widowed, and the construction of new mosques in Bahrain.^[2]

Hessa bint Salman Al Khalifa died on 4 August 2009 at the Al-Sakhir Palace in Bahrain.^[3] Her funeral was held on 6 August 2009 at the Isa bin Salman Grand Mosque in Riffa, Bahrain.^[4] Her funeral was attended by a number of dignitaries including her son, Hamad ibn Isa Al Khalifah, Khalifah ibn Salman Al Khalifah, Salman bin Hamad bin Isa Al Khalifa and other male members of the Al Khalifa family.^[4] Other officials, diplomats, parliamentarians and government ministers were also present.^[4]

Hamad ibn Isa Al Khalifah announced that a new charity was to be established in his mother's name.^[2] The goal of the new charity would be to promote causes championed by his mother within Bahrain.^[2]

• Honorary President of the Children & Mothers Welfare Society.
• Honorary President of the International Ladies Association.