Isay_reaction

Isay reaction

Isay reaction

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The Isay reaction also known as Gabriel-Isay condensation is an organic reaction in which certain diaminopyrimidines are transformed into pterins by condensation with a 1,2-dicarbonyl compound, such as 2,3-butanedione.[1][2] The reaction is named after Oskar Isay.

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  1. [1]
    Isay, Oskar (1906). "Eine Synthese des Purins". Berichte der Deutschen Chemischen Gesellschaft. 39: 250–265. doi:10.1002/cber.19060390149..
  2. [2]
    Kaufman, Seymour; Storm, Carlyle B.; Shiman, Ross (1971). "Preparation of 6-substituted pterins via the Isay reaction". The Journal of Organic Chemistry. 36 (25): 3925–3927. doi:10.1021/jo00824a016..


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