Barcelona

Jeffrén played three full seasons with FC Barcelona B,^[4] suffering Segunda División B relegation in 2006–07 and scoring six goals in 30 games the following season in an immediate promotion. On 8 November 2006, at the age of 18, he made his debut with the first team, against CF Badalona in a Copa del Rey round-of-32 match, coming on as a substitute for Javier Saviola in the 83rd minute of a 4–0 home win (6–1 on aggregate).^[5]

Impressed at the player's performance for the reserves, first-team manager Pep Guardiola called Jeffrén for the 2008–09 pre-season, where he played all seven matches scoring twice, including once on 30 July against ACF Fiorentina in the 47th minute of a 3–1 victory.^[6] On 17 May 2009, he made his first La Liga appearance (of two in the season), as already crowned champions Barcelona lost 1–2 at RCD Mallorca.^[7]

On 19 December 2009, Jeffrén replaced Thierry Henry late into the FIFA Club World Cup final against Estudiantes de La Plata.^[8] Two days later, he picked up a leg muscle injury that left him out for 4–5 weeks in a 1–1 friendly draw with Kazma SC in Kuwait, in commemoration of the Asian side's 45th anniversary.^[9]

On 10 February 2010, Barcelona announced Jeffrén had signed a contract extension with the club, keeping him at the Camp Nou until 30 June 2012 with a buyout clause set at €10 million.^[10][11][12] On the 14th, he started as right back in a 2–1 loss at Atlético Madrid.^[13]

On 3 April 2010, Jeffrén scored his first top-division goal after a low cross from Eric Abidal, in a 4–1 home defeat of Athletic Bilbao.^[14] On the 24th he added another in spectacular fashion, in a 3–1 home win over Xerez CD^[15] and, as the Catalans renewed their domestic supremacy, finished the campaign with 18 official appearances.

Jeffrén appeared less for Barça's first team in 2010–11.^[16] On 29 November 2010, he came from the bench to close the scoring in El Clásico against Real Madrid, in a 5–0 home victory.^[17]

Sporting CP

On 4 August 2011, Sporting CP signed Jeffrén for €3.75 million, plus €200,000 in bonus. He penned a five-year contract with a buy-out clause of €30 million. In addition, if the Lisbon club sold the player for a fee higher than €3.75M, Barcelona would receive 20% of the added value/differential value;^[18][19] the Catalans also retained an exclusive buy-back option for €8 million and €12 million, in 2012 and 2013 respectively.^[20]

Jeffrén played his first competitive match with Sporting on 13 August 2011, in a 1–1 home draw against S.C. Olhanense.^[21] He spent the vast majority of the first half of his first season sidelined with physical problems.^[22]

Jeffrén returned to action on 11 March 2012, and only needed 12 minutes on the pitch to score two goals in a 5–0 home victory over Vitória de Guimarães.^[23] He contributed only 13 league games in his second year, and was deemed surplus to requirements subsequently.^[24][25]

Valladolid

On 1 February 2014, Jeffrén returned to the Spanish top flight when he joined Real Valladolid on a two-and-a-half-year deal.^[26] He made his debut on 9 February at home against Elche CF, coming on at half time for Víctor Pérez: he crossed the ball for Humberto Osorio's 2–2 equaliser, but only a minute later left the pitch with a muscular injury after his team had already used all three substitutes.^[27]

Jeffrén scored his first goal for Valladolid on 2 November 2014, coming off the bench to score an 81st-minute winner in a 2–1 win against Girona FC at the Estadio Nuevo José Zorrilla that put his team on top of the second division table.^[28] He finished the campaign with three goals from 35 appearances, the other two coming in each fixture against former side Barcelona B – the first being a 7–0 thrashing on 21 December.^[29]

On 29 August 2015, Jeffrén terminated his contract with the Castile and León club.^[30]

Eupen

On the same day as leaving Valladolid, Jeffrén signed a three-year deal at K.A.S. Eupen from the Belgian Second Division.^[31] He made his debut on 13 September, replacing Guy Dufour in the 57th minute of a 1–4 home loss to K. Lierse SK. He scored his first goal for his new team thirteen days later, an added-time strike to seal a 3–1 win over R. White Star Bruxelles at the Kehrwegstadion.^[32]

On 3 October 2015, Jeffrén netted twice in a 5–1 rout at K.S.K. Heist.^[33] He finished the season with three goals in 17 matches, as the side came third and were promoted to the Belgian First Division A for administrative reasons.^[34]

Later years

Jeffren signed for Grasshopper Club Zürich of the Swiss Super League on a two-year deal on 9 July 2017.^[35] He left in late January 2019 for AEK Larnaca FC in the Cypriot First Division^[36] and, one year later, switched to the Croatian First Football League with NK Slaven Belupo.^[37]

After a brief spell with Al Dhaid SC in the United Arab Emirates, Jeffrén signed with Lamphun Warriors F.C. of the Thai League 2 in June 2021.^[38]

Spain youth

Jeffrén was part of the Spain under-19 squad that won the 2006 UEFA European Championship, playing eight matches and scoring three goals.^[39] Shortly after, he was called by Venezuela national team coach Richard Páez for the 2007 Copa América, but eventually did not switch allegiance due to injury.^[40]

On 6 February 2009, Jeffrén received his first under-21 callup. In 2011 he was selected by manager Luis Milla for the European Championships in Denmark, appearing in three games and scoring in the semi-final against Belarus (3–1 win)^[41] as the national team won their third trophy in the category.^[42]

Venezuela

Following his Spanish international youth spell, Jeffrén showed openness to represent Venezuela at senior level,^[43] an option he himself had discarded in 2010 when he was consulted by a journalist of his native country.^[44] On 19 March 2015, however, he acquired the necessary paperwork,^[45] being called up for the first time on 18 August^[46] and winning his first cap on 8 September by playing 31 minutes in a 1–1 friendly with Panama.^[47]