Spring

In the first half of 2016 Jet Setting raced in the colours of the Equinegrowthpartners Syndicate. She began her second season in a maiden race over eight and a half furlongs on heavy ground at Cork Racecourse on 26 March in which she was ridden for the first time by Shane Foley who became her regular jockey. Racing against less experienced rivals she started 2/1 favourite and drew away in the last furlong and a half to win "comfortably" by two and a half lengths from the Dermot Weld trained Creme e La, with a gap of ten lengths back to the third placed horse.^[9] The ground was heavy again fifteen days later when the filly was stepped up in class for the Group Three 1000 Guineas Trial over seven furlongs at Leopardstown Racecourse and started the 11/2 second choice in the betting behind the Aidan O'Brien-trained Alice Springs. After being sent to the front by Foley from the start she broke clear of her opponents at half way and stayed on well to win by three lengths from Now Or Never with Alice Springs in third.^[10]

Jet Setting was then sent to England for the 203rd running of the 1000 Guineas on 1 May over Newmarket's Rowley Mile. Racing on faster ground she started a 33/1 outsider and finished ninth of the sixteen runners behind Minding after being hampered a furlong from the finish. The ground was softer three weeks later when the filly contested the Irish 1000 Guineas at the Curragh and started third favourite behind Minding and Now Or Never, who had won the Derrinstown Stud 1,000 Guineas Trial. She had not been among the original entries for the race, meaning that her owners had to pay a supplementary fee of €30,000 to secure a place in the field.^[11] The other runner included Coolmore (C. L. Weld Park Stakes), Pretty Perfect (Salsabil Stakes) and Tanaza (Silver Flash Stakes). Jet Setting raced in second place behind Pretty Perfect before going to the front after three furlongs. Minding moved up alongside her inside the final furlong but she rallied strongly when challenged and won by a head with the pair finishing ten lengths clear of the other eight runners.^[12][13] Keatley commented "It's a dream, really. Miracles happen. She was a cheap purchase and she's done the business."^[14] Shane Foley said "She's a tough little filly and the ground came right for her – she ran a blinder at Newmarket but it was too fast for her. Soft ground and a stiff mile was ideal for her".^[11]

Summer

On 13 June Jet Setting was put up for auction at the Goffs London Sale, held at Kensington Palace Orangery and was bought for £1,300,000 by Mike Wallace for the China Horse Club.^[15] Commenting on his decision to buy the filly Wallace said "She's a Classic winner. There's very few of them around and her form has stacked up very well. She's a game filly, she's sound and very athletic. Fillies of that quality are highly sought after by anybody. Part of our philosophy is looking for long-term breeding opportunity, she allows us that but she also has potential racing upside".^[16]

Four days later she started favourite for the Coronation Stakes at Royal Ascot but after leading for most of the way she faded in closing stages and dead-heated for sixth behind the French-trained Qemah.

Autumn

After a break of two and a half months Jet Setting returned in the Group One Matron Stakes over one mile at Leopardstown on 10 September. She was in contention for most of the way but weakened towards the finish and came home sixth of the eight runners behind Alice Springs. On 2 October the filly was dropped in class for the Group Three Concorde Stakes at Tipperary Racecourse in which she was matched against male opposition for the first time in 2016. Racing on her favoured soft-to-heavy ground she started the 7/4 favourite ahead of nine opponents including The Happy Prince (Renaissance Stakes), Flight Risk (Gladness Stakes), Sruthan (winner of the race in 2013) and Creggs Pipes (Cairn Rouge Stakes). After racing in second behind Creggs Pipes, Jet Setting took the lead in the straight and pulled away to win "easily" by six and a half lengths.^[17] Jet Setting ended her racing career with a run in the Queen Elizabeth II Stakes at Ascot on 15 October. Starting a 25/1 outsider she was among the early leaders but faded in the last quarter mile and finished eleventh of the fourteen runners behind Minding.