John_M._Sedivy

John M. Sedivy

John M. Sedivy

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John Michael Sedivy is the Hermon C. Bumpus Professor of Biology and a professor of Medical Science at Brown University. He is listed as a F1000 Prime faculty member and on Who's Who in Gerontology. He has published over 130 original articles.[1]

Quick Facts Academic background, Education ...

He wrote the first book on gene targeting in 1992.[2] In 2006, he published the first comprehensive in vivo quantification of cellular senescence in aging primates. That year, his lab also discovered how (through the Polycomb pathway) c-Myc contributes to the regulation of chromatin states. His research has found that mice missing one copy of the Myc transcription factor live longer than wild-type mice.[3]

He is co-Editor-in-Chief of the journal Aging Cell, and is chair of the 2015 Gordon Research Conference on the Biology of Aging.

Bibliography

Books

  • Sedivy, J. M., & Joyner, A. L. (1992). Gene targeting. WH Freeman and company. ISBN 9780195099683

Selected publications

  • Sedivy, J. M., & Sharp, P. A. (1989). Positive genetic selection for gene disruption in mammalian cells by homologous recombination. Proceedings of the National Academy of Sciences, 86(1), 227–231.

Awards

References

  1. [1]
    Researchers at Brown Profile
  2. [2]
    Gene Targeting
  3. [3]
    "Benefits of Missing MYC". The Scientist Magazine®.
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