KIF4A

KIF4A

KIF4A

Protein-coding gene in the species Homo sapiens


Kinesin family member 4A is a protein that in humans is encoded by the KIF4A gene.[5][6]

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Function

Kinesins, such as KIF4A, are microtubule-based motor proteins that generate directional movement along microtubules. They are involved in many crucial cellular processes, including cell division.[6]

Interactions

KIF4A has been shown to interact with HMG20B[7] and DNMT3B.[8]

Clinical significance

NTCP is the entry receptor for both Hepatitis B (HBV) and Hepatitis D viruses (HDV).[9] KIF4 was found to play an essential role in HBV and HDV infection through its regulation of the retrograde transport of NTCP from the cytoplasm to the cell surface where it acts as a receptor for HBV/HDV infection.[10]


References

  1. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  2. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. Ha MJ, Yoon J, Moon E, Lee YM, Kim HJ, Kim W (Jun 2000). "Assignment of the kinesin family member 4 genes (KIF4A and KIF4B) to human chromosome bands Xq13.1 and 5q33.1 by in situ hybridization". Cytogenetics and Cell Genetics. 88 (1–2): 41–42. doi:10.1159/000015482. PMID 10773663. S2CID 46074226.
  4. Lee YM, Kim W (September 2003). "Association of human kinesin superfamily protein member 4 with BRCA2-associated factor 35". The Biochemical Journal. 374 (Pt 2): 497–503. doi:10.1042/BJ20030452. PMC 1223617. PMID 12809554.
  5. Geiman TM, Sankpal UT, Robertson AK, Chen Y, Mazumdar M, Heale JT, et al. (2004). "Isolation and characterization of a novel DNA methyltransferase complex linking DNMT3B with components of the mitotic chromosome condensation machinery". Nucleic Acids Research. 32 (9): 2716–2729. doi:10.1093/nar/gkh589. PMC 419596. PMID 15148359.
  6. Yan H, Zhong G, Xu G, He W, Jing Z, Gao Z, et al. (November 2012). Chen ZJ (ed.). "Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus". eLife. 1: e00049. doi:10.7554/eLife.00049. PMC 3485615. PMID 23150796.

Further reading



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