Kelliphite

Kelliphite

Kelliphite

Chemical compound

Kelliphite is an acronym for the organophosphorus compound 6,6'-[(1,1'-Biphenyl-2,2'-diyl)bis(oxy)]bis[4,8-di-tbutyl-1,2,10,11-tetramethyl]dibenzo[d,f][1,3,2]dioxaphosphepin. This chiral ligand is widely used in asymmetric synthesis.[1][2] In one example, this ligand is used to form a rhodium complex to catalyze asymmetric hydroformylation of prochiral olefins. It has been shown that high substrate concentrations as well as a wide variety of functional groups are tolerated. [3]

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References

  1. [1]
    Clark, Thomas P.; Landis, CR; Freed, SL; Klosin, J; Abboud, KA (2005). "Highly Active, Regioselective, and Enantioselective Hydroformylation with Rh Catalysts Ligated by Bis-3,4-diazaphospholanes". J. Am. Chem. Soc. 127 (14): 5040–2. CiteSeerX 10.1.1.601.7762. doi:10.1021/ja050148o. PMID 15810837.
  2. [2]
    Cobley, Christopher J.; Gardner, K; Klosin, J; Praquin, C; Hill, C; Whiteker, GT; Zanotti-Gerosa, A; Petersen, JL; Abboud, KA (2004). "Synthesis and Application of a New Bisphosphite Ligand Collection for Asymmetric Hydroformylation of Allyl Cyanide". J. Org. Chem. 69 (12): 4031–40. doi:10.1021/jo040128p. PMID 15176828.
  3. [3]
    Cobley, Christopher J.; Klosin, Jerzy; Qin, Cheng; Whiteker, Gregory T. (2004). "Parallel Ligand Screening on Olefin Mixtures in Asymmetric Hydroformylation Reactions". Org. Lett. 6 (19): 3277–80. doi:10.1021/ol0487938. PMID 15355031.
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