Kir2.2

KCNJ12

KCNJ12

Protein-coding gene in the species Homo sapiens

ATP-sensitive inward rectifier potassium channel 12 is a lipid-gated ion channel that in humans is encoded by the KCNJ12 gene.[5][6][7][8][9]

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Function

This gene encodes an inwardly rectifying K+ channel that may be blocked by divalent cations. This protein is thought to be one of multiple inwardly rectifying channels that contribute to the cardiac inward rectifier current (IK1). The gene is located within the Smith–Magenis syndrome region on chromosome 17.[9]

Interactions

KCNJ12 has been shown to interact with:

See also

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000184185 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000042529 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Hansen, SB (May 2015). "Lipid agonism: The PIP2 paradigm of ligand-gated ion channels". Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1851 (5): 620–8. doi:10.1016/j.bbalip.2015.01.011. PMC 4540326. PMID 25633344.
  6. [6]
    Wible BA, De Biasi M, Majumder K, Taglialatela M, Brown AM (Mar 1995). "Cloning and functional expression of an inwardly rectifying K+ channel from human atrium". Circulation Research. 76 (3): 343–50. doi:10.1161/01.res.76.3.343. PMID 7859381.
  7. [7]
    Kaibara M, Ishihara K, Doi Y, Hayashi H, Ehara T, Taniyama K (Nov 2002). "Identification of human Kir2.2 (KCNJ12) gene encoding functional inward rectifier potassium channel in both mammalian cells and Xenopus oocytes". FEBS Letters. 531 (2): 250–4. doi:10.1016/S0014-5793(02)03512-3. PMID 12417321. S2CID 46515689.
  8. [8]
    Kubo Y, Adelman JP, Clapham DE, Jan LY, Karschin A, Kurachi Y, Lazdunski M, Nichols CG, Seino S, Vandenberg CA (Dec 2005). "International Union of Pharmacology. LIV. Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509–26. doi:10.1124/pr.57.4.11. PMID 16382105. S2CID 11588492.
  9. [9]
    "Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12".
  10. [10]
    Leonoudakis D, Conti LR, Anderson S, Radeke CM, McGuire LM, Adams ME, Froehner SC, Yates JR, Vandenberg CA (May 2004). "Protein trafficking and anchoring complexes revealed by proteomic analysis of inward rectifier potassium channel (Kir2.x)-associated proteins". The Journal of Biological Chemistry. 279 (21): 22331–46. doi:10.1074/jbc.M400285200. PMID 15024025.
  11. [11]
    Leonoudakis D, Conti LR, Radeke CM, McGuire LM, Vandenberg CA (Apr 2004). "A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels". The Journal of Biological Chemistry. 279 (18): 19051–63. doi:10.1074/jbc.M400284200. PMID 14960569.
  12. [12]
    Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C (Mar 2001). "Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97". Journal of Cell Science. 114 (Pt 5): 987–98. doi:10.1242/jcs.114.5.987. PMID 11181181.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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