After Detective Michael Long is shot and left for dead, he is saved by the eccentric billionaire, Wilton Knight and his associate Devon Miles. He is given a new face by plastic surgery, a new identity as Michael Knight, and the Knight Industries Two Thousand (KITT for short) – a dream car with super-spy gadgets and nearly invulnerable armor. Wilton asks Michael to carry on his crime-fighting crusade believing "one man can make a difference." Soon Michael manages to locate his shooter, a woman named Tanya Walker, who is stealing technology secrets from a computer company and selling them to the highest bidder. With the help of a woman named Maggie, Michael lures Tanya into a trap by showing off KITT's abilities as bait.

• Note: Originally shown as a feature-length Pilot TV Movie, which was later cut into two separate episodes for syndication.
• Guest stars: Lance LeGault (Colonel Roderick Decker on The A-Team), Richard Anderson (Oscar Goldman on The Six Million Dollar Man and The Bionic Woman) and Ed Gilbert (Fenton Hardy on The Hardy Boys/Nancy Drew Mysteries)

Michael helps a stranded Army Lieutenant named Robin Ladd who learns her father has died in a suspicious accident. Michael conducts his own investigation which leads to uncovering the theft of nuclear warheads from an Army weapons depot and evidence the top brass may be involved.

Michael plans a rock-climbing holiday in the small town of White Rock. There he experiences bullying, even against nice young boy Davey, and an equally coward sheriff more interested in keeping the peace than enforcing the law. Michael tries to help when the Scorpions motorcycle gang moves in, but gets incarcerated and escapes. He deals with them himself and finds out they expect the rival gang Road Dogs for a confrontation which would wreck the town.

Devon instructs Michael to investigate corporate raider Lawrence Blake, who buys mortgages and firms which all 'happen to' go broke shortly after. The next prey is Sammy Phillips's private stock car and motor vehicle stunts show, which he runs with his son Mark, a would-be motorbike stuntman. Michael infiltrates as new stunt driver after Sammy has a suspicious accident. Driving Kitt, stunts are almost too easy. Blake's goon Bill Gordon attempts to sabotage the show, although he has an inside accomplice.

Guest stars: Marc Alaimo (Gul Dukat on Star Trek: Deep Space Nine)

Devon assigns Michael to protect Senator Maggie Flynn, a close friend to Devon, who has made enemies in her political crusade to fight a new energy bill. After numerous attempts on her life, Michael arranges for her to hide out with Devon, much to Devon's chagrin, while he conducts an investigation with Flynn's assistant Jane Adams, who suspects a rival politician to be involved in the attacks.

Michael and K.I.T.T. are sent to protect a group of ranchers whose water supply is being cut off by a wealthy landowner. Michael meets his match in a hotheaded young widow who leads the fight for their rights and is instructed to make sure she doesn't do anything too impulsive.

Devon Miles is arrested on a traffic violation in Lyndhurst Flats and ends up sharing a jail with Frank Reston, the very journalist he was planning to meet. When Reston is killed by the corrupt police officers because he had too much evidence against them and a corrupt judge that controls them, Devon's life is now on the line because he is the only witness to see Reston alive. Michael teams up with Frank's ex-wife Carol in his search for Devon and expose the corruption to the proper authorities.

Two petty thieves, Tony and Rev (William Sanderson), break into a Foundation warehouse and unwittingly reactivate KARR (the Knight Automated Roving Robot) (voiced by Peter Cullen), which was sitting in storage. Responding to the break in, Michael and KITT arrive to see the two thieves make a getaway in KITT's identical twin. After Michael learns that KARR was KITT's prototype and programmed with an unstable self-preservation AI, he goes after the vehicle which the two thieves are using to crash into bank vaults. Things become more complicated when KARR has the thieves kidnap Bonnie so she can repair a malfunctioning circuit. Michael and KITT managed to get Bonnie back, and try to disable KARR using a laser. When this fails, Michael sets KITT on a direct collision course with KARR, betting on KARR's self-preservation to defeat him.

Michael captures a criminal named Dugan and takes his place as Colonel Kincaid's new driver. His goal is to find out for what purpose Kincaid is building his own private task team and catch him red-handed.

Cheryl Burns, an old friend of Michaels, has been accused of murder. Michael asks for some time off to search out the only man who can clear Cheryl: accountant Marty King, a 'Woody Allen' type. However Marty is a person of interest by the police to expose his crooked employer for "cooking the books".

This episode was dedicated to R.A. Cinader, stating "he was an original".

Devon Miles has organized an anti-terrorism treaty between three rather unstable third world nations. Michael is assigned to find a plant (and possible hit-man) amongst the security team. He joins them during their special training session at Redmond's Victory Academy. However Michael wonders if this is the work of one person or a team.

Michael Knight is staying at a beach house with the daughter of newly elected president of the South American country of San Marada. His assignment is to protect both her and her father. A young woman named Micki overhears the conspirators' plot to assassinate El Presidente. She is kidnapped, but escapes the car by jumping from a cliff. Michael manages to rescue Micki, though she ends up with temporary amnesia. Can the only witness remember in time before the assassination can take place?

Note: This is the final episode to be directly supervised by series creator Glen A. Larson, fulfilling his original contact with Universal. While Larson would continue to be credited as Executive Producer throughout the run of the series and would offer his comments on script drafts, Robert Foster would take over as showrunner beginning with the next episode.

Michael goes to Texas to meet Father Carlos Laguna, whose family is feuding with a group of gunrunners in possession of an advanced assault rifle called the X-19. The situation worsens when Carlos' brother Roberto is shot with an X-19 during a drive-by attack. With the help of a bartender named Angie, Michael poses as a gun collector and makes contact with the gunrunners where he offers to buy the whole shipment of X-19s. They strike a deal, but Angie tricks Michael and steals his suitcase full of money, which was charity funds provided by Devon.

Note: KITT's voice modulator is finally upgraded for the first time into the trio of digital bars seen during the remainder of the series run as first seen in K.A.R.R Knight Automated Roving Robot in his debut appearance.

Michael and KITT enter the Alternative 2000, a cross country race for cars that run on alternative fuel. They are there to find a saboteur, not to win, but find themselves having to rescue nosy reporter Liberty Cox in each lap. The mastermind is the ambitious TV broadcaster sponsor of the race and a member of the race safety crew.

A high-profile "skin magazine" editor named Philip Royce is murdered and Michael helps his daughter Lauren investigate who killed him and why. The clues may be found in Royce's computer, but the file he was working on is password protected under the code name "Topaz". The plot thickens when a private investigator Royce hired calls Lauren to reveal the story, but the man is killed by a sniper. Lauren and Michael then follow the P.I.'s leads to Las Vegas in hopes of uncovering the meaning behind Topaz, but quickly come across more thugs who want them eliminated.

Michael travels to Alpine Crest posing as a skip-tracer in pursuit of a counterfeiter. There he and KITT find out CIA is keeping an eye on a much bigger operation. Michael's only ally is a local journalist, while taking on a group of corrupt police officers aligned with the counterfeiter.

Bonnie is given the honor of joining the Helios society, whose members all have genius level I.Q.'s. This to Devon's chagrin, who was expecting a nomination himself, but has to be content with honorary membership. However, it soon becomes clear that high ranking members of the society are planning to ensure their own survival by committing the perfect crime. For this they need to get their hands on KITT and to get rid of its driver, Michael Knight.

Michael learns that the woman he was once engaged to, Stephanie Mason (Catherine Hickland), has been arrested for her involvement in a money laundering scheme. Unfortunately, he was engaged to her when he was Michael Long and Stephanie thinks he is dead. The Justice Department has given Stephanie the option of turning in her boss Gilbert Cole, or face conspiracy charges if she refuses. The situation intensifies when Cole sends thugs to eliminate her before she can testify before a grand jury. Now Michael must protect the woman he once loved and capture the people who are setting her up, all the while avoiding slip ups that may give away his secret identity.

A shipment of highly sensitive Micro-Tech electronic components is stolen near Albuquerque, New Mexico. When Michael goes to investigate, he finds himself attracted to the cause of the Alliance of Independent Truckers, who have lost 6 shipments. He is also attracted to AIT spoke-person and lady trucker Terri 'The Tiger' Calley.

A CEO of an electronics firm (Robert Ginty) hires the Foundation to help catch whoever is stealing software from his company. Michael suspects someone on the inside – a programmer named Julian Groves (Tony Dow) when he learns of his involvement with a con-woman named Connie Chason. Soon an overzealous private investigator named Flannery Roe (Gail Edwards), hired by Grove's wife, gets into Michael's way, but things become more complicated when Connie is found murdered in Julian's bungalow and the programmer is on the run. Michael doesn't believe Julian is capable of murder and he and Flannery are forced to tolerate each other to find the real killer.

Michael picks up a hitchhiker who's looking for her daughter. When he defends her from a couple of bikers from the Satan's Stompers motorcycle club, he ends up charged with second degree murder himself. The only reason she is reluctant is because her husband, the leader of the gang, has her daughter and she has the evidence that can put him away.