Early career

San Giacomo's first television appearances were four episodes on three television series during 1987.^[8] Two notable appearances were in Crime Story in 1988 for the episode "Protected Witness" (season 2/episode 13) as Theresa Farantino and in Miami Vice in 1989 for the episode "Leap of Faith" (season 5, episode 21) as Tania Lewis. The Miami Vice episode also featured a guest appearance by her future husband, actor Cameron Dye, one year before their marriage. Previously, she was featured on the daytime soap opera All My Children as Louisa Sanchez, the Latina common-law wife of Mitch Beck (Brian Fitzpatrick) whose presence threatened to thwart his relationship with Hillary Martin (Carmen Thomas).

San Giacomo first drew international attention in Steven Soderbergh's Sex, Lies, and Videotape (1989), which was her film debut as a credited actor (in the 1988 movie Miles from Home, her role as Sandy was not credited).^[8] Her work in the film was nominated for a Golden Globe Award, and she received a Los Angeles Film Critics Association New Generation Award. The film was honored with the Cannes Film Festival's prestigious Palme d'Or.

In 1990, San Giacomo played a supporting role as Julia Roberts's character's wisecracking roommate Kit De Luca in Pretty Woman. The film generated $178 million at the box office.^[9]

San Giacomo also has appeared in Quigley Down Under (1990), Vital Signs (1990), Under Suspicion (1991), Once Around (1991), Where the Day Takes You (1992), Nina Takes a Lover (1994), and Suicide Kings (1997). She also appeared as Nadine Cross in the Stephen King miniseries The Stand with Rob Lowe, which landed them on the cover of the May 7–13, 1994 issue of TV Guide. She continued doing films, and as 1999 ended, she did the film Eat Your Heart Out. In 2001, San Giacomo landed the starring role in the Jenifer Estess bio-pic Jenifer.

San Giacomo did voice work for the animated series Gargoyles (as the character of Fox). However, she went uncredited for the role because her agent believed it would damage her reputation to have worked on an animated series.

Just Shoot Me!

Needing to work, but not wanting to be away from her newborn son for months at a time, San Giacomo shifted to television in the role of hot-tempered, sassy journalist Maya Gallo in Just Shoot Me! (1997–2003).^[10] Her character was partially based on an unproduced idea that executive producer Steven Levitan once had in mind for actress Janeane Garofalo when he was a writer for The Larry Sanders Show. San Giacomo was cast in the starring role because the series was meant to center on her character; however, the show soon adopted an ensemble style. Despite the shift in focus, San Giacomo remained an integral part of the show, and she received top billing. She and the four other main cast members appeared in all 148 episodes of the series, which lasted until 2003.

San Giacomo's work during season 2 (1997–1998) earned her a Golden Globe Award nomination in 1998 for Best Actress in a Television Comedy or Musical.

Post-Just Shoot Me! and appearances

After NBC cancelled Just Shoot Me! in 2003, San Giacomo appeared sporadically on television and in films. She made guest appearances on several television series, including the short-lived crime drama The Handler in 2003 and Unscripted in 2005. She was the narrator for the series Snapped: Killer Couples. San Giacomo also appeared in the 2005 films Checking Out and Havoc as well as the 2006 film Conquistadora. San Giacomo was to have made her return to television on The WB's new drama Related in 2005, but the character was recast due to creative differences. Kiele Sanchez took her place as Anne Sorelli on the show. San Giacomo also made few public appearances; she made her first public appearance in nearly a year on 19 October 2005 at the 15th Annual Environmental Media Awards. She made two more public appearances at the Crystal and Lucy Awards on 6 June 2006 and at the 3rd Annual Alfred Mann Foundation Innovation and Inspiration Gala on 9 September 2006.

In 2006, San Giacomo returned to network television with three guest appearances on the third season of Veronica Mars. She reunited with Enrico Colantoni from Just Shoot Me!, playing Harmony Chase. Both Colantoni and San Giacomo enjoyed their reunion so much that they lobbied for their characters to appear together in more episodes.^[11]

In September 2006, San Giacomo secured her first starring role on a television program after Just Shoot Me! when she reunited with fellow Carnegie-Mellon alum Holly Hunter in the series Saving Grace. San Giacomo played Grace's best friend Rhetta Rodriguez.

In June 2010, San Giacomo guest-starred in the episode titled "Death Becomes Her" on the series In Plain Sight. She played a woman from an organized crime family with a terminal illness. In December 2011, San Giacomo appeared on the episode titled "Beards" on Hot in Cleveland as Caroline, Melanie's estranged sister.

Film

Television