Leonardo da Vinci High School is a high school temporarily housed on the east side of Buffalo, New York. There are 400 students enrolled in da Vinci spanning grades 9–12. The high school serves Grades 9 through 12. The current principal is Gregory Lodinsky.

Leonardo da Vinci was originally housed on the 4th Floor of the Koessler Administration Building (KAB) on the D'Youville College Campus and shared space with the Grover Cleveland High School for electives. The school moved to Madonna Hall building on the D'Youville College campus. Students who attended DaVinci had the opportunity to take college credit-bearing classes from D'Youville. In August 2023, the school was temporarily relocated to 167 East Utica Street.

Leonardo da Vinci High School offers varsity sports including:

• Soccer
• Volleyball (Female only)
• Cross Country
• Swimming
• Bowling
• Basketball
• Softball/Baseball
• Track
• Tennis

Students who are interested in playing a sport da Vinci does not offer are able to try out at Hutchinson Central Technical High School.^{[citation needed]}

• India Walton – American political activist, democratic socialist^[2]

• Official website