Hanson goes undercover to investigate a series of burglaries at a high school, and learns that the burglar and a student are both obsessed with one of the teachers that work there, Miss Chadwick.

The entire group investigates the rape and murder of a 16-year-old girl by going undercover in a private school, most of whose student body consists of children from affluent families.

Hoffs is sent to a Catholic school for girls to investigate a possible arsonist with all leads headed towards a rambunctious student. Meanwhile, Penhall is mugged by his date at a bowling alley.

While mourning the loss of Jenko in a drunk driving crash, Hanson and Hoffs are assigned to get close to a school principal after he gets death threats from the leader of a gang he humiliated. He then gets held hostage along with the 300 students at the school and it's up to Hanson, Hoffs, Ioki and Penhall to save them with the help of their new captain.

Note: First appearance of Steven Williams (Adam Fuller).

While busting drug dealers, Hanson and Penhall (in their "McQuaid brothers" cover) discover a girl who is being sexually abused by her father, a high-ranking police officer.

A 16-year-old crack dealer is mysteriously murdered and the Jump Street squad goes undercover in the seedy world of narcotics and prostitution.

The Jump Street squad puts a sting on a bar serving alcohol to underage kids and ironically discover their own captain has been arrested for drunk driving.

Hanson goes undercover and is trapped inside an in-patient adolescent abuse center while investigating reports from Hanson's first Jump Street case that the center is mistreating patients.

Hanson comes to blows with a new partner, officer Dennis Booker, whom he suspects is as bigoted as the gang of racists they're to bust.

While trying to infiltrate a high school computer club, Penhall is picked on by a bully who prompts stories from each of the cops who were all terrorized by a bully at some time in their lives.

Booker solves the case that gets Hanson out of prison, then resigns from the police force.

Penhall works as a bouncer in a sports bar while Hanson goes undercover to bust up a college gambling operation. The officers study for a detective's exam.

The death of a lesbian professor finds Hoffs and Fuller going undercover at a university. A student teacher's assistant develops romantic feelings for Fuller.

Hanson is invited to witness the execution of Ronnie Seebook, who is on death row for murdering a convenience store clerk, and asks the condemned inmate to make a film to scare off children from becoming criminals.

Hanson and Penhall investigate the drug related death of a basketball star and stumble into a point shaving scheme.

Hanson and Penhall go to El Salvador to look for Doug's missing wife and find themselves in the middle of political turmoil. They return home with Marta's nephew to be raised by Penhall.

Guest star: Richard Roundtree.

A handicapped policewoman is sent in undercover to investigate a series of attacks on handicapped women and Hoffs is sent in by Fuller undercover, in a wheelchair.

The officers tell their version of the story of how they saved a Senator from an assassin, each story with them as the hero. This was the last episode of season 4 that Johnny Depp was filmed in.

After Penhall abandons Ioki on a stake-out for a personal emergency, he is reassigned to uniformed patrol. At his new precinct, Penhall becomes involved with a group of corrupt officers while befriending rookie cop Dean Garrett–whom the other officers accuse of being a plant for Internal Affairs.

Note: This episode marks the final appearance of Dustin Nguyen on the series. First recurring appearance of David Barry Gray (Dean Garrett).

After the power goes out during a storm, Penhall, Hanson and Hoffs find themselves at the mercy of a violent gang in school.

Note: This episode marks the final appearance of Johnny Depp on the series. This is the final episode of the series to air on Fox.

In his first Jump Street assignment, Dean Garrett goes undercover with Hoffs in a massage parlor believed to be the front for a drug ring. Garrett takes an interest to a worker in the parlor, who turns out to be an undercover DEA officer.

Notes: First recurring appearance of Alexandra Powers (Kati Rocky). This was the first episode to air in first-run syndication.

Former DEA agent Kati Rocky has joined the Jump Street program, and partners with Garrett to investigate a recurrence of drug dealing at a school recently busted by the other officers. Garrett's estranged brother makes an unannounced visit, and Garrett discloses he was adopted while Rocky confesses to having dropped out of high school. Meanwhile, Detective Hoffs purchases her first home.

Notes: Final recurring appearances of Sal Jenco, David Barry Gray, and Alexandra Powers. This episode was originally produced for Season 4. Departed cast members Johnny Depp and Dustin Nguyen are featured in the opening sequence.

Officer Tony McCann joins Jump Street and is partnered with a mentally-impaired teen in a school buddy system to investigate the death of the teen's former buddy.

Doug's younger brother Joey joins Jump Street. After being rejected by Doug, he volunteers to go undercover in a cult and soon becomes brainwashed by their leader and a pretty girl who shows him love.

Doug's life enters limbo while doctors struggle to save him after being shot. He begins to make life-altering career choices after talking with those he meets there.

Mac tries to solve the mystery of why a famous reporter's daughter had been missing.

Mac goes undercover for the FBI by dating the daughter of a notorious drug dealer while trying to rekindle a romance with an old flame.

Mac and Joey try to find who is responsible for a series of robberies at a retirement home with one suspect being the son of Fuller's girlfriend.

Note: This episode marks the final appearance of Michael DeLuise in the series. Absent: Holly Robinson.

Mac enters a devil worship cult whose leader can lure boys to join them with her beauty.

Hoffs is brought to court after being charged with a civil suit for arresting a man for solicitation.

Mac goes undercover as a football player after the school's star player dies from a heart attack. He uncovers toxic waste being dumped along a stream which runs under the football field–and that a teammate's father may be responsible.

Hoffs infiltrates a girl gang to find who is responsible for a murder of a teen she witnessed.

Hoffs and Mac investigate a car theft ring with the prime suspect being one of Hoffs' own students.